探讨多囊卵巢综合征不孕患者的治疗方式

A study of different treatment of infertile patients with polycystic ovary syndrome

目的：探讨多囊卵巢综合征不孕患者的治疗方式。方法选取郑州市妇幼保健院2013年9月至2014年9月收治的132例多囊卵巢综合征不孕患者作为研究对象，根据治疗方式的不同分为观察组和对照组，对照组患者采取氯米芬、尿促性素和绒毛膜促性素激素促进排卵治疗，观察组患者先口服2个周期的去氧孕烯及8周的二甲双胍，再给予对照组方法治疗，比较两组患者治疗前后体质量、月经周期、卵巢体积、黄体生成素和睾酮水平的变化情况以及卵巢排卵率和半年内的妊娠率。结果经有效治疗后，两组患者体质量、卵巢体积、黄体生成素和睾酮水平与治疗前比较差异均有统计学意义（P﹤0.05）；观察组排卵率和半年内的妊娠率显著优于对照组，两组比较差异有统计学意义（ P﹤0.05）。结论采用去氧孕烯联合二甲双胍促排卵治疗多囊卵巢综合征不孕患者，其临床治疗效果明显优于单纯促排卵治疗，该方法值得在临床推广应用。

objective To investigate the treatment of infertile patients With polycystic ovary syndrome（ PCoS）. Methods one hundred and thirty-tWo infertile patients With polycystic ovary syndrome from September 2013 to September 2014 Were selected as research subjects,they Were divided into observation group and control group according to the differ-ent forms of treatment. The patients of control group Were treated With clomiphene,human menopausal gonaotropin（ hMg） and human chorionic gonadotropin hormone to promote ovulation,the patients of observation group Were given tWo periods o-ral desogestrel and eight WeeKs of metformin firstly,then folloW the method of treatment of the control group. The body Weight,ovarian volume,the changes of lh and testosterone levels,ovulation rate and pregnancy rates Within six months Were compared after treatment. Results After effective treatment,the body Weight,ovarian volume,the changes of lh and testosterone levels of tWo groups had significant differences（ P﹤0. 05 ）;the ovulation rate and pregnancy rates Within six months of the observation group Were significantly better than those of the control group（ P﹤0. 05 ）. Conclusions In terms of the treatment of infertile patients With polycystic ovary syndrome,the clinical effect of desogestrel combined With metformin on promote ovulation is significantly better than simply promote ovulation.