阿替普酶治疗急性肺栓塞高危患者80例临床研究

Effect of alteplase on 80 patients with severe acute pulmonary embolism

目的：探讨采用阿替普酶对急性肺栓塞高危患者进行治疗的临床效果。方法随机选取2012年9月至2014年12月收治的急性肺栓塞高危患者80例，按照治疗方法的不同将其分为观察组和对照组，观察组患者采用阿替普酶进行溶栓治疗，对照组患者采用尿激酶进行溶栓治疗，对两组患者的临床效果进行回顾性分析。结果观察组患者的临床治疗总有效率明显高于对照组患者，差异有统计学意义（ P﹤0.05）。结论采用阿替普酶治疗急性肺栓塞高危患者，效果显著，能够有效促进患者临床症状的改善，对于提高患者的生活质量，保障患者的生命安全具有十分重要的意义，建议在临床上进一步推广。

objective To investigate the effect of alteplase on patients With severe acute pulmonary embolism. Methods From September 2012 to December 2014,80 cases of high-risK acute pulmonary embolism Were selected,ac-cording to the different treatment methods,they Were divided into observation group and control group,the observation group Were treated With alteplase dissolved suppository treatment,the control group Were treated With uroKinase thrombolytic therapy,the clinical effects of the tWo groups Were analyzed retrospectively. Results The clinical effective rate in observa-tion group Were significantly higher than that in control group,the difference Was significant（ P﹤0. 05）. Conclusions U-sing alteplase treatment of acute pulmonary embolism in high-risK patients,the effect is significant,can effectively promote the improvement of the clinical symptoms of the patient,for improving the quality of life of patients,to protect the safety of patients,it is recommended to be further promoted in clinical practice.