紫杉醇与顺铂联合化疗治疗宫颈癌

Curative effect of paclitaxel and cisplatin combined chemotherapy on cervical cancer

目的观察紫杉醇与顺铂联合化疗治疗宫颈癌的临床疗效。方法选择2011年3月至2013年6月收治的55例符合纳入与排除标准的宫颈癌患者并随机分为两组，观察组行紫杉醇与顺铂联合（TP）方案，对照组行5-氟尿嘧啶联合顺铂（FP）方案，比较两组治疗有效率与不良反应发生率。结果观察组治疗有效率为75．00％（21／28），高于对照组的59．38％（13／27），差异有统计学意义（P〈0．05）。两组厌食、脱发、骨髓抑制、恶心呕吐、过敏反应、疲乏无力等不良反应发生率比较差异均未见统计学意义（P均〈0．05）。结论紫杉醇与顺铂联合化疗治疗宫颈癌疗效显著，可有效控制肿瘤，不良反应较轻、患者可耐受，为晚期宫颈癌主要治疗手段，值得临床借鉴。

Objective To observe the effect of paclitaxel and cisplatin combined chemotherapy on cervical cancer. Methods Fifty -five patients meeting with the criteria of inclusion and exclusion and who had cervical cancer admitted into Zhumadian central hospital from March 2012 to June 2013 were selected and randomly divided into two groups. The observation group was treated with paclitaxel combined with cisplatin （TP）while the control group with 5- fluorouracil combined with cisplatin （FP）. The effective rate of treatment and the occurrence rate of adverse reactions of the two groups were com- pared. Results The effective rate of the observation group was 75.00% （21/28）, which was higher than 59. 38% （13/27） of the control group and the difference was significant（P 〈 0. 05）. The comparison of the rate of adverse reactions of the two groups such as anorexia, hair loss, bone marrow suppression, nausea and vomiting, allergic reactions, fatigue and others had no statistical significance. Conclusions The curative effect of paclitaxel and cisplatin combined chemotherapy on cervical cancer is significant, and can effectively control the tumor. With less side effects, the treatment can be tolerated by patients and as the main means of the treatment of advanced cervical cancer, so it＇s worthy of clinical reference.