IL-8、IL-18水平与PCI术后支架再狭窄的关系

Relationship between the levels of IL-8, IL-18 and coronary in-stent restenosis after PCI

目的探讨支架植入术后白细胞介素-8（IL-8）、白细胞介素-18（IL-18）水平与支架内再狭窄的关系。方法选择172例接受经皮冠脉支架植入术（PCI）并于术后6个月复查冠脉造影患者，检测术前、术后24h及术后6个月血浆IL-8、IL-18水平。结果支架内再狭窄组与无支架内再狭窄组术后24h IL-8、IL-18水平均较术前增高（P〈0．05）；支架内再狭窄组与无再狭窄组相比术后半年IL-8、IL-18水平明显增高（P〈0．01）。结论定期监测血浆IL-8、IL-18水平对预测支架内再狭窄具有一定意义。

Objective To investigate the relationship between coronary in-stent restenosis and the levels of IL-8, IL-18. Methods A total of 172 patients underwent PCI got coronary angiography after 6 months, and the levels of IL-8, IL-18 before surgery, after 24 hours and after six months were detected. Results After 24 hours, the levels of IL-8, IL-18 of the in-stent restenosis group and the no in-stent restenosis group increased than those before operation（P 〈 0.05） ; Compared with the levels of IL-8, IL-18 of the no in-stent restenosis group after 6 months, the in-stent restenosis group significantly incerased（P 〈 0.01 ）. Conclusions Regular monitoring the levels of IL-8, IL-18 has some significance in forecasting the coronary in-stent restenosis.