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抑制性氨基酸受体及其递质对突触可塑性的影响 被引量:4

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摘要 神经系统的正常功能是以兴奋性和抑制性之间的相对平衡为基础的。CNS过度兴奋会导致失眠、癫痫、感官功能下降等一系列病理状态。因此,抑制性作用对人类为维持正常的生理功能是十分重要的。在中枢神经系统中,抑制性氨基酸及其受体介导的突触传递起着主要的抑制作用,可以作为治疗癫痫、疼痛、帕金森综合症等疾病的新的作用靶点。
机构地区 皖南医学院
出处 《科技视界》 2016年第13期276-277,288,共3页 Science & Technology Vision
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  • 1Allain AE,Le Corronc H,Delpy A,Cazenave W,Meyrand P,Legendre P,Branchereau.Maturation of the GABAergic transmission in normal and pathologic motoneurons[J].Neural Plast 2011,13:183-215.
  • 2Sandkuhler J,Chen JG,Cheng G,Randic M.Low-frequency stimulation of afferent Ad-bers induces long-term depression at primary afferent synapses with substantia gelatinosa neurons in the rat[Z].J Neurosci1997,17:6483-6491.
  • 3Kriegstein AR,Owens DF.GABA may act as a self-limiting trophic factor at developing synapses[J].Sci STKE.2001,95:14-31.
  • 4Kaeser GE,Rabe BA,Saha MS.Cloning and characterization of GABAAγsubunits and GABABsubunits in Xenopus laevis during development[J].Dev Dyn2011,240(4):862-873.
  • 5Somogyi P,Takagi H,Richards JG,Mohler H.Subcellular Localization of Benzodiazepine/GABA,Receptors in the Cerebellum of Rat,Cat,and Monkey Using Monoclonal Antibodies[Z].J Neurosci1989,9(6):2197-2209.
  • 6Farrant M,Nusser Z.Variations on an inhibitory theme:phasic and tonic activation of GABA(A)receptors[J].Nat Rev Neurosci 2005,6(3):215-229.
  • 7Kullmann DM,Ruiz A,Rusakov DM,Scott R,Semyanov A,Walker MC.Presynaptic,extrasynaptic and axonal GABAA receptors in the CNS:where and why?Prog Biophys Mol Biol 2005,87:33-46[Z].
  • 8Brickley S,Cull-Candy S,Farrant M.Development of a tonic form of synaptic inhibition in rat cerebellar granule cells resulting from persistent activation of GABAA receptors.J Physiol 1996,497:753-759[Z].
  • 9Chadderton P,Margrie TW,Hausser M.Integration of quanta in cerebellar granule cells during sensory processing.Nature 2004,428:856-860[Z].
  • 10Walker MC,Semyanov A.Regulation of excitability by extrasynaptic GABA(A)receptors[J].Results Probl Cell Differ 2008,44:29-48.

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