门冬胰岛素和人胰岛素对妊娠期糖尿病患者母婴结局的影响

Door winter insulin and human insulin and outcomes in patients with gestational diabetes

目的比较门冬胰岛素和人胰岛素治疗妊娠期糖尿病对母婴结局的影响。方法选取2012年1月~2015年1月我院收治的妊娠糖尿病患者98例作为研究对象,将其随机分为门冬胰岛素组和人胰岛素组,各49例。治疗4周后,比较两组孕妇空腹血糖、餐后血糖、糖化血红蛋白（HbA1c）、低血糖发生率以及婴儿结局。结果门冬胰岛素和人胰岛素均能有效地控制血糖,门冬胰岛素组低血糖发生率显著低于人胰岛素组,差异有统计学意义（P〈0.05）。结论在妊娠期糖尿病的治疗中,与人胰岛素相比,门冬胰岛素吸收速度更快,起效和达到峰值时间更短,低血糖发生率更低,值得临床推广应用。

Objective To compare the effect of Insulin aspart and Insulin Human on pregnant woman with gestational diabetes mellitus and infant outcome.Methods Data of 98 pregnant women with GDM in our hospital from January 2012 to January 2015 were reviewed.Data of fasting blood glucose, postprandial blood sugar,glycosylated hemoglobin,incidence of hypoglycemia and infant outcome were compared between the two groups cured with different Insulin for 4 weeks.Results Insulin aspart and Insulin Human could effectively control the blood sugar respectively.There are two hypoglycemia pregnant women in Insulin aspart group and seven in Insulin Human group,significant statistics difference has been found between the two groups,P0.05.Conclusion Contrast with Insulin Human group,rate of Insulin aspart absorption was higher,effect of peak time was shorter and incidence of hypoglycemia was lower than the group.It is worth utilizing Insulin aspart in GDM cure.