摘要
目的:本文旨在探讨Is期睾丸混合性生殖细胞瘤的不同治疗方法。方法:对2008年2月至2012年6月收治3例(年龄26~39岁)入院的Is期睾丸混合性生殖细胞瘤患者的临床资料进行回顾性分析和总结,并结合文献就该期肿瘤的临床特征进行探讨。结果:3例患者中1例只行根治性睾丸切除术,1例行根治性睾丸切除术+腹膜后淋巴结清扫术+BEP方案化疗,1例行根治性睾丸切除术+放疗。混合性生殖细胞瘤病理成分分别为左侧95%未成熟畸胎瘤、精原细胞瘤合并5%绒癌、胚胎性癌成分,左侧75%精原细胞瘤合并25%胚胎性癌、畸胎瘤成分,右侧90%成熟性畸胎瘤合并10%卵黄囊瘤。随访24个月3例患者肿瘤无局部复发和远处转移。结论:对于Is期睾丸混合性生殖细胞瘤诊断主要依靠体格检查、超声、MRI、血清肿瘤标记物测定等,确诊需要病理学检查,根治性睾丸切除术是其基础的治疗方法。
Objective: To investigate different treatment methods for stage-Is testicular mixed germ cell tumors( TMGCTs).Methods: We retrospectively analyzed the clinical data about 3 cases of stage-Is TMGCTs( aged 26- 39 years) treated in the 175 th Hospital of PLA,reviewed relevant literature,and explored the clinical characteristics of TMGCTs. Results: Of the 3 patients,1 was treated by radical orchiectomy,1 by radical orchiectomy + retroperitoneal lymph node dissection + BEP chemotherapy scheme,and the other by radical orchiectomy + radiotherapy. The pathological components of TMGCTs were immature teratoma,seminoma,spermatocytoma,chorioepithelioma,embryonal carcinoma,and yolk sac tumor. No recurrence or distant metastasis was found during the24-month follow-up after surgery. Conclusion: The diagnosis of TMGCTs primarily depends on physical examination,ultrasonography,MRI,and measurement of serum tumor markers,while its confirmation necessitates pathological examination,and its treatment is basically radical orchiectomy.
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2016年第5期437-441,共5页
National Journal of Andrology