阴茎Peyronie病动物模型研究进展

Animal models of Peyronie's disease: An update

Peyronie病以阴茎白膜局部纤维斑块形成为特征,在临床中相对少见。国内外与之相关的基础研究甚少,除疾病本身相对少见外,可能与疾病动物模型的不确定性有一定关系。目前较常用的Peyronie病动物模型各存利弊,其中转化生长因子β1(TGF-β1)与Fibrin白膜下注射缺乏阴茎弯曲、钙/骨化等特征;手术创伤可能建立Peyronie病急性期模型;自发模型则可能带来全身多组织器官纤维化与人Peyronie病表现不一等不足。模型的选择对基础研究至关重要,因此,本文通过回顾Peyronie病相关的动物研究模型,为该病基础研究提供参考。

Peyronie＇s disease is characterized by local fibrosis of the tunica albuginea and relatively rare clinically. Few relevant basic researches could be retrieved,which might be attributed to the absence of a robust animal model of the disease as well as to its rareness. At present,some animal models available for Peyronie＇s disease have their own merits and demerits. TGF-β1-induced and Fibrin-induced models are lack of penile curvature and calcification / ossification. A surgical model might be established for the acute phase of the disease. The characteristic of a widespread fibrotic process involving many organs in the spontaneous model is quite different from that of human Peyronie＇s disease. Therefore,choosing the right model is essential for researches. This paper presents an overview of the animal models of Peyronie＇s disease,meant to provide some reference for the basic research of the disease.