产ESBLs肺炎克雷伯菌感染呼吸道的危险因素分析

Study on the risk factors of ESBLs- producing Klebsiella pneumoniae which infection the respiratory tract

目的:探讨产ESBLs肺炎克雷伯菌感染呼吸道的危险因素。方法:收集123株肺炎克雷伯菌,采用双纸片协同法检测ESBLs,根据产ESBLs情况,把肺炎克雷伯菌分为A组(ESBLs阳性组,57株)和B组(ESBLs阴性组,66株),统计产ESBLs肺炎克雷伯菌的感染危险因素,采用χ2检验和多因素Logistic回归分析数据。结果:">60岁"、"ICU"、"侵入性操作"、"住院患者"、"住院天数>14 d"、"Charlson并发症指数>3"和"死亡"在A组和B组间的差异明显(P<0.01),"侵入性操作"和"住院天数>14 d"在A组和B组间差异有统计学意义(P<0.05)。结论:众多因素与产ESBLs肺炎克雷伯菌感染呼吸道关系密切,其中"侵入性操作"和"住院天数>14 d"是独立危险因素。

Objective To investigate the risk factors of extended spectrum β - lactamase （ESBLs） producing Klebsiella pneumoniae （KP） which infection the respiratory tract. Method No repeat 123 strains of KP were collected From October 2013 to October 2014： Double disc synergy method was used to detect the ESBLs. The KP were defined as group A （ ESBLs positive Group ,57 strains） and group B （ ESBLs - negative group,66 strains） which according to the result of double disc synergy meth- od. The risk factors of KP infection were statistical, and the chi - square test and multifactor logistic regression analysis were used by data analysis. Results ＂ 〉 60 years＂,＂ 1CU＂ ,＂invasive procedures＂ ,＂ hospitalized patients＂,＂ hospitalization 〉 14 days＂, ＂complications of charlson index 〉 3 ＂ and ＂death＂ were differences between the group A and group B （ P 〈 0. 1 ）. ＂Invasive procedures＂ and ＂hospitalization days 〉 14＂ were statistically significant difference between group A and group B （P 〈 0. 05 ） . Conclusion A number of risk factors closely related to the ESBLs - producing Klebsiella pneumoniae infection the respiratory tract,and the ＂invasive procedures＂ and ＂ hospitalization 〉 14 days＂ are independent risk factor.