摘要
目的 研究血管紧张素Ⅱ - 1型受体 (AT1R)基因A1 1 66/C和 β纤维蛋白原 (FBG) - 4 55G/A双位点多态性与中国人群冠心病 (CHD)发生的相关关系。方法 采用聚合酶链反应—限制性片段长度多态性 (PCR -RFLP)检测法 ,测定 1 2 4例CHD患者和 1 4 4例对照者的AT1RA1 1 66C和 β -FBG - 4 55G/A基因型。 结果 发现CHD组AT1RAA基因型和AC基因型频率与对照组相比均无统计学差异 ,而对双位点进行分析 ,在二组间亦未发现差别。结论 AT1R基因A1 1 66/C与 β-FBG - 4 55G/A多态性与CHD的发生发展似无直接关系。
Objective To study the association of angiotensin II-1 (AT1R) gene A1166/C and Beta-bibrinogen Gene G/A-455 polymorphisms with the development of coronary heart disease (CHD). Methods With PCR-RFLP method, At1R gene A1166/C genotype and Beta-fibrinogen Gene G/A-455 polymotphisms were determined in 124 CHD patients and 144 controls. Results There is no statistical difference in the frequencies of AT1R genotype AC and AA between the CHD patients and the controls, and no differences are found between CHD and polymorphisms of these two gene loci either. Conclusion AT1R gene A1166/C and Beta-fibrinogen Gene G/A-455 polymorphisms play no role in the occurrence of CHD.
出处
《中国煤炭工业医学杂志》
2002年第8期749-751,共3页
Chinese Journal of Coal Industry Medicine
基金
20 0 0年珠海市科委重点科技项目 [2 0 0 0 (45) 36]
广东省科技厅重点科研项目 [2 0 0 0 (2 61 ) 66]
