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非细胞因子来源的天然蛋白质作为人类疫苗佐剂的研究进展

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摘要 疫苗接种不仅是现代医学预防传染病的常用方式和重要手段,也已成为肿瘤预防与治疗的研究热点。疫苗效能的充分发挥离不开佐剂的应用。许多疫苗本身含有非特异性佐剂,它们可以增强疫苗刺激机体产生免疫应答的作用。研究发现,多种生物来源的天然蛋白质也可作为佐剂应用于疫苗接种中,并且与传统佐剂相比,天然蛋白质用作佐剂有其独特的优势。本文主要就非细胞因子来源的天然蛋白质作为疫苗佐剂的应用现状及其免疫机制的最新研究进展进行综述。
出处 《现代免疫学》 CAS CSCD 北大核心 2016年第3期245-249,共5页 Current Immunology
基金 国家自然科学基金(31370904) 上海市浦江人才计划资助(15PJD021) 上海市科委生物医药领域科技支撑项目(15401900500)
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