B细胞特异性激活蛋白在神经内分泌肿瘤中的表达

Expression of PAX5 in Neuroendocrine Neoplasms

目的:观察B细胞特异性激活蛋白(PAX5)在神经内分泌肿瘤(NEN)中的表达。方法:经证实为NEN病例标本56例,用免疫组化SP法检测其石蜡包埋肿瘤组织中PAX5和Ki67表达,比较PAX5在不同肿瘤大小(肿块直径≤2 cm或>2 cm)、Ki67表达率(Ki67≤20%或>20%)及TNM分期(早期或晚期)中的表达情况。结果:PAX5在Ki67>20%病例中的阳性表达率(59.52%)高于Ki67≤20%病例(21.43%),在晚期病例(62.16%)高于早期病例(26.32%),差异有统计学意义(P<0.05);在不同肿块直径病例中的阳性率比较,差异无统计学意义(P=0.78)。结论:PAX5在NEN中有一定表达,表达与肿瘤增殖活性(Ki67表达率)及TNM分期有关。

Objective： To observe the expression of B cell-specific activator protein（ PAX5） in neuroendocrine neoplasms（ NENs）. Methods： 56 confirmed NEN cases specimens were enrolled in this study. Immunohistochemical SP method was adopted to detect the expression of Pax5 and Ki67 in paraffin embedding tumor tissues. The positive expression rates of Pax5 was compared in different tumor size（ mass diameter≤2 cm or 2 cm）,in different Ki67 expression rates（ Ki67≤20% or 20%） and in different TNM stage（ early or late stage）. Results： The positive expression rate of Pax5 in Ki67 20% cases was 59. 52%,significantly higher than 21. 43% in Ki67 ≤ 20% cases（ P 0. 05）. The positive expression rate of Pax5 in late stage was 62. 16%,significantly higher than 26. 32% in early stage（ P 0. 05）. There was no statistically significant difference in positive expression rate of Pax5 between different tumor size（ P = 0. 78）. Conclusion： There is a certain degree of expression of Pax5 in NENs,which is related to the proliferation activity of the tumor（ Ki67 expression rate） and the TNM stage.