载药金纳米粒的研究进展

Research progress of drug-loading gold nanoparticles

近年来,作为一种新型药物递送系统,金纳米粒已引起了广泛关注。由于其特殊的物理化学性质,能与多种类型药物发生相互作用,如蛋白质、核酸、小分子药物等,从而可应用于肿瘤治疗和检测。笔者对载药金纳米粒的制备方法、载药方式和安全性等问题进行综述。

In recent years, as a novel drug delivery system, gold nanoparticles have attracted widespread attention. Be- cause of their special physicochemical properties, such as quantum size effect, unique optical phenomenon, easily reacting with thiol eompounds or disulfides and so on, gold nanoparticles can delivery variety of types of drugs, like proteins, nucleic acid, small molecular drugs, therefore they can he applied in tumor treatment and detection. In this paper the preparation of drug- loading gold nanoparticles, their drug-loading ways and safety issues were reviewed.