青葙总皂苷对肝损伤保护作用的研究

Study of total celosins on liver protection in different liver damage model

目的探讨青葙总皂苷(CES)对肝损伤的保护作用。方法建立小鼠急性肝损伤、大鼠慢性肝损伤以及小鼠免疫性肝损伤模型,并对实验动物肝功能、肝脂质过氧化指标以及病理组织进行检测和观察。结果 CES各剂量组可不同程度地降低血清ALT、AST;能显著性降低肝组织匀浆中MDA的含量,同时还可以提高SOD活性,并呈一定的剂量依赖关系;病理组织学观察显示,给药组动物肝细胞受损程度明显减轻。结论 CES对CCl_4所致小鼠急性肝损伤、大鼠慢性肝损伤以及刀豆蛋白A所致免疫性肝损伤均有保护作用,其保肝作用可能与其抗氧化作用有关。

Objective To study the liver protection of total celosins （CES） in different liver damage models. Method A- cute liver damage mouse model, chronic liver damage rat model and immune liver damage mouse model were established for this study. Liver function tests, liver lipid peroxidation indicators and liver pathology were observed. Results CES of each dose group can lower serum ALT and AST in different degrees, can significantly reduce the content of MDA in liver homogenate, while can increase SOD activity. Pathological examination showed that animals administered significantly reduced the degree of liver cell damage. Conclusion CES have protective effects on acute liver damage induced by CCL, chronic liver damage induced by CC14 and immunological liver damage induced by concanavalin A. Its hepatoprotective effect may be related to its antioxidant effects.