炎症标志物与颈动脉粥样斑块的稳定性

Stability of Inflammatory Markers and Carotid Artery Plaque

动脉粥样硬化是一种全身系统性疾病,主要影响人体的大、中动脉。同时其与炎症反应密切相关,因炎症反应产生的一些生物标志物,如C反应蛋白和白介素-6等可作为心血管终点事件的可靠预测指标。既往的一些临床研究多为探索炎症标志物与亚临床的动脉粥样硬化之间的关系,即颈动脉内膜中层厚度。然而,炎症标志物与颈动脉粥样斑块稳定性之间的关联尚不可知。现综述炎症生物标志物与颈动脉粥样斑块稳定性之间的关系。

Atherosclerosis is a systemic disease that primarily affects the body＇s large arteries. At the same time it is closely related to inflammation,some of the biomarkers produced by inflammation,such as C-reactive protein and interleukin-6 can be used as a reliable predictor of cardiovascular outcome events. Some clinical studies exploring the relationship between mostly markers of inflammation and subclinical atherosclerosis,that is,carotid intima-media thickness. However,markers of inflammation associated with carotid plaque stability still unknown. This article reviewed the relationship between biomarkers of inflammation and carotid artery plaque stability.