线粒体能量代谢异常与病理性心肌肥大的研究进展

Mitochondrial Energy Metabolism and Pathological Cardiac Hypertrophy

病理性心肌肥大是临床常见的适应性改变过程,伴随着能量代谢类型的转变及线粒体生物学功能的衰退,是心血管疾病发生率和病死率增高的独立危险因素。肥大心肌细胞能量代谢异常与多条信号通路异常关系密切,改善能量代谢异常有望成为逆转心肌肥大和延缓心力衰竭进程治疗的新靶点。

Pathological cardiac hypertrophy is a coadaptive process accompanied by metabolic profile change and mitochondrial bioenergetic decline,and is an independent predictor of higher rate of cardiovascular events and mortality. Many signaling pathways are involved in the maladaptive metabolism of hypertrophied hearts,and targeting abnormal metabolism is likely the new therapy of hypertrophic prevention and reversion.