血清神经元特异性烯醇化酶与早产儿脑损伤相关性的研究

Correlation Between Brain Injury and Serum Neuron-specific Enolase in Premature Infants

目的:探讨血清神经元特异性烯醇化酶(NSE)的改变与早产儿脑损伤的发病,损伤程度的影响关系。方法:诊断为早产儿脑损伤30例为观察组,排除早产儿脑损伤30例为对照组,抽血查NSE,比较两组NSE水平,根据头颅MRI分为轻度脑损伤组和重度脑损伤组,比较两组NSE水平。结果:早产儿脑损伤组与非脑损伤组NSE水平差异有统计学意义(t=6.346,P<0.01),重度脑损伤组NSE水平高于轻度脑损伤组,但差异无统计学意义(t=1.790,P>0.05)。结论:NSE增高与早产儿脑损伤的发病相关,可做为早产儿脑损伤诊断参考指标。

Objective： To study the coorelation between the chang of serum neuron-specific enolase（ NSE） and the onset and degree of brain damage in premature infants. Methods： 30 premature infants who were diagnosed as brain injury were classified as observation group,30 premature infants without brain injury as control group. Serum neuron-specific enolase in the two group were checked; NSE in the two groups were compared. The brain injury premature infants were divided into mild group and severe group according to cranial MRI. NSE levels of the two different sets were compared. Results：The differences in NSE between brain injury group and nin-brain injury were significant（ t = 6. 346,P﹤0. 01）. The difference was not significant between mild group and severe group in the levels of NSE（ t = 1. 790,P﹤0. 05）. Conclusion： NSE increases with the onset of brain damage in premature infants. NSE could be a reference factor for brain injury in premature infants.