缺血性脑卒中后白质损伤与神经血管单元的研究进展

White Matter Injury After Ischemic Cerebral Stroke and the Research Process of Neural Vascular Unite

缺血性脑卒中损伤是一个多环节级联效应过程,它由多种损伤机制共同参与,它不仅严重损伤灰质,还引起严重的白质损伤。近年来随着神经血管单元(neurovascular unit,NVU)概念的提出和对其认识的深入,使不同原因所导致的脑卒中均被视为大脑神经血管单元参与的反应损伤过程。为了对神经血管单元损伤与保护机制的更深入全面的理解,为缺血后脑卒中的治疗靶点提供依据,本文将从白质与NVU的损伤和保护机制进行阐述。

Ischemic stroke damage process is a cascading effect. A variety of mechanisms take part in it,whitch causes not only a serious damage of gray matter,but also severe white matter damage. In recent years,as the neurovascular unit（ NVU） concept being put forward and understood deeply,it makes stroke caused by different reasons be regarded as the damage process involved in the reaction of brain blood vessels units. Comprehensive understanding of NVU damage and protection mechanisms provides the basis directly for therapeutic targets about ischemia stroke. This article will depict the damage and protection mechanisms of white matter and NVU.