肝癌冷冻消融治疗的临床应用分析

Analysis of the clinical application of cryoablation for liver cancer

目的:探讨肝癌冷冻消融治疗的临床应用。方法:选择2012年2月至2015年10月间70例氩氦刀冷冻治疗的肝癌患者为观察组,另选择同时期采取经导管肝动脉化疗栓塞治疗的70例肝癌患者为对照组,观察比较两组肝癌患者的甲胎蛋白(Atpa-fatoprotein,AFP)转阴率、肿瘤完全坏死率、12个月及24个月生存率、不良反应等情况的差异。结果:观察组AFP转阴率、肿瘤完全坏死率、12个月生存率均高于对照组(P<0.05),两组24个月生存率比较差异无统计学意义(P>0.05);观察组患者术后的不良反应发生率低于对照组(P<0.05)。结论:氩氦刀冷冻是治疗肝癌的有效方法之一,能提高近期生存率,减少并发症。

Objective： To discuss the clinical application of cryoablation for liver cancer. Methods： 70 cases of liver cancer treated with argon- helium cryosurgery from February 2012 to October 2015 were enrolled as the observation group,while 70 cases of liver cancer treated with transcatheter arterial chemoembolization were assigned as the control group. The recovery rate of Atpa- fatoprotein（ AFP）,the rate of complete tumor necrosis,the survival rates of 12 months and 24 months and adverse reactions between the two groups were compared and analyzed. Results： The recovery rate of AFP,the rate of complete tumor necrosis,and the survival rates of 12 months in the observation group were higher than those of the control group（ P 〈 0. 05）,but there was no difference in 24- month survival rate between the two groups（ P 〉 0. 05）. The incidence of adverse reactions in the observation group was lower than that of the control group（ P 〈 0. 05）. Conclusion： Argon- helium cryoablation is one of effective methods for the treatment of liver cancer,which can improve the short- term survival rate and reduce complications.