美沙拉嗪与柳氮磺吡啶治疗溃疡性结肠炎的疗效对比

Comparative study on the curative efficacy of mesalazine and sulfasalazine in the treatment of ulcerative colitis

目的:探讨美沙拉嗪与柳氮磺吡啶治疗溃疡性结肠炎的疗效。方法:选取164例溃疡性结肠炎的患者随机分为观察组(82例)和对照组(82例),观察组给予美沙拉嗪治疗,对照组给予柳氮磺吡啶治疗。结果:两组治疗后溃疡性结肠炎活动指数评分、C反应蛋白、治疗有效率、不良反应发生率进行比较,差异均有统计学意义(P<0.05)。结论:本次研究认为美沙拉嗪治疗溃疡性结肠炎疗效肯定,不良反应少,值得临床推广。

Objective： To investigate the curative effect of mesalazine and sulfasalazine in the treatment of ulcerative colitis. Methods： 164 cases of ulcerative colitis were selected and randomly divided into the study group（ 82 cases） and the control group（ 82 cases）. The Study group was given mesalazine and the control group was given sulfasalazine. Results： There were statistically significant differences in the ulcerative colitis activity index score,C- reactive protein results,the effective rate and the incidence of adverse reaction after treatment between the two groups（ P 〈 0.05）. Conclusion： Mesalazine in the treatment of ulcerative colitis is effective with fewer adverse reactions,which is worthy of promotion.