老年骨质疏松性骨折患者血清生化指标检测及风险评估

Detection of serum biochemical indices and fracture risk assessment of elderly patients with osteoporotic fracture

目的探讨老年骨质疏松性骨折患者血清生化指标检测及骨折风险评估(FRAX)。方法选取2010年12月—2013年12月我院收治的老年骨折疏松性骨折患者80例作为研究组,另选取健康体检者40例为对照组,对比两组骨特异性碱性磷酸酶(B-ALP)、骨钙素(BGP)、甲状旁腺激素(PTH)、Ⅰ型胶原蛋白N-端肽(s-PINP)及I型胶原蛋白C末端交联端肽(s-CTX)的水平,并应用FRAX评价两组骨折再发生率。结果研究组B-ALP和PTH水平显著高于对照组,s-PINP和s-CTX水平显著低于对照组,差异具有统计学意义(P<0.05),研究组和对照组BGP水平差异无统计学意义(P>0.05),研究组患者骨折再发生率组显著高于对照组,差异具有统计学意义(P<0.05)。结论老年骨质疏松性骨折患者血清B-ALP、PTH、s-PINP和s-CTX水平异常,FRAX可以有效预测骨折风险。

Objective To explore detection of serum biochemical indices and fracture risk assessment（FRAX）of elderly patients with osteoporotic fracture.Methods 80 cases with osteoporotic fractures were selected from our hospital from December 2010 to December 2013,which was acted as research group,in addition,40 cases of healthy were also selected as the control group.bone-specific alkaline phosphatase（B-ALP）,osteocalcin（BGP）,parathyroid hormone（PTH）,I collagen N-terminal peptide（s-PINP）and type I collagen C-terminal cross-linking level terminal peptide（sCTX）of two groups were compared.The recurrence rate of two groups was evaluated by FRAX.Results The B-ALP and PTH of research group were significantly higher than the control group,s-PINP and s-CTX is significantly lower than the control group,the difference was statistically significant（P0.05）,difference of BGP between research group and the control group was not statistically significant（P0.05）.The incidence of fractures again of research group was significantly higher than the control group,which the difference was statistically significant（P0.05）.Conclusion The levels of serum B-ALP,PTH,s-PINP and s-CTX in elderly osteoporotic fracture patients were abnormal,and FRAX can effectively predict the fracture risk.