原发性开角型青光眼与24h眼压及眼灌注压的研究进展

Research progress of primary open angle glaucoma,24h intraocular pressure and ocular perfusion pressure

原发性开角型青光眼是一类早期无明显临床症状,但随病情进展将导致不可逆的视神经损害及视野缺损的致盲性眼病。眼压是原发性开角型青光眼诊断及评定治疗效果的简单而又重要的指标。临床上,一些治疗中的原发性开角型青光眼患者白天就诊时间所测眼压已达靶眼压,但视神经损害却仍在进展,研究表明可能与夜间眼压的升高、24h较大的眼压波动及夜间眼灌注压的降低有关。因此,我们对原发性开角型青光眼与眼压及眼灌注压波动的相关文献予以综述,以更好的理解三者之间的关系。

Primary open angle glaucoma（ POAG） is one of the eye diseases which can lead to blindness. The early symptomof POAG is unconspicuous, however, it will result in irreversible optic never damage and visual field defect with the disease progress. As an index for diagnosing and evaluating the therapeutic effect of POAG, intraocular pressure（ IOP） is simple and important. Clinically,although some treated patients have a target IOP at clinic time,the optic never damage still get worse. Researches indicate that higher nocturnal IOP and 24 h IOP variation and lower nocturnal ocular perfusion pressure（ OPP） may be the reasons for this phenomenon. The following essay will give an overviewof POAG,IOP and OPP according to the relevant literatures so that we can have a better understanding.