摘要
近年来,随着对不同类型乳腺癌基因表达谱研究的深入,表观遗传调节剂用来调控乳腺癌异常表达基因而应用于临床。初步结果表明,DNA甲基转移酶和组蛋白去乙酰化酶抑制剂对不同类型的乳腺癌(包括耐药性乳腺癌)均有不同的治疗作用。本文从体外实验研究、临床试验方面,分别对将来可能应用于乳腺癌治疗的表观遗传调节剂进行综述。
Recent researches on gene expression profiles linked to the different types of breast cancer cells have led to consider the use of epigenetic modulators to modulate the expression of genes deregulated in cancer. The preliminary encouraging results have demonstrated a positive effect of DNA methyl transferase and histone deacetylase inhibitors on different types of breast cancer, as well as drug-resistant cells. In this review, we will describe the different epigenetic modulators currently used or investigated in breast cancer therapy research in vitro as well as clinical trials, and promising compounds, which might be used in future breast cancer therapies.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2016年第5期413-417,共5页
Cancer Research on Prevention and Treatment
