老年2型糖尿病视网膜病变患者炎性指标与抗磷脂抗体水平变化的研究

Changes of inflammatory markers and anti-phospholipid antibody levels in elderly patients with type 2 diabetic retinopathy

目的观察老年2型糖尿病合并视网膜病变患者血清炎性指标和抗磷脂抗体水平的变化。方法选择老年2型糖尿病患者104例,根据有无视网膜微血管病变分为糖尿病无视网膜病变组(A组,32例)、糖尿病伴非增殖期视网膜病变组(B组,42例)和糖尿病伴增殖期视网膜病变组(C组,30例);检测各组患者血清中空腹血糖(FBG)、高敏C反应蛋白(hs-CRP)、白细胞计数(WBC)和抗心磷脂抗体(ACA)水平,并对检测结果进行统计学处理和分析。结果 FBG水平C组高于B组和A组,C、B 2组与A组比较,差异均有统计学意义(P<0.05),B组与C组比较差异无统计学意义(P>0.05);hs-CRP、ACA水平C组均高于B组和A组,3组间比较差异有统计学意义(P<0.05);而WBC水平3组间比较差异无统计学意义(P>0.05)。结论老年2型糖尿病患者hs-CRP、ACA水平与视网膜病变的严重程度密切相关,可作为预测老年2型糖尿病患者并发视网膜微血管病变的重要指标。

Objective To observe the changes of serum inflammatory markers and anti-phospholipid antibody levels in elderly patients with type 2diabetic retinopathy.Methods A total of 104 cases of elderly patients with type2 diabetes were chosen.According to the condition of retinal microvascular lesions,patients were divided into the diabetes without retinopathy group（A group,n=32）,diabetes with nonproliferative diabetic retinopathy group（B group,n=42）and diabetes with proliferative diabetic retinopathy group（C group,n=30）.The fasting blood glucose（FBG）,high-sensitivity C-reactive protein（hs-CRP）,white blood cell（WBC）and anticardiolipin antibody（ACA）were detected and the detection results were statistically analyzed.Results The level of FBG in group C was higher than that in group B and A,the differences were statistically significant（P0.05）,and the difference between group B and group C had no statistical significance（P0.05）.The levels of hs-CRP and ACA in group C were significantly higher than those in group B and A,the difference among the three groups had statistical significance（P0.05）.However,the WBC level had no statistically significant difference among the three groups（P0.05）.Conclusion The levels of hsCRP and ACA in elderly patients with type 2diabetes are closely related to the severity of retinopathy,which could be used as the important indexes for predicting the retinopathy in elderly patients with type 2diabetes.