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蛋白激酶C在血管收缩中的调节机制 被引量：3

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摘要 血管的收缩可以调节血管紧张度,引起血流量和血压的变化。在高血压、糖尿病等慢性疾病的发病过程中,蛋白激酶C（PKC）信号通路表达异常会引起血管收缩功能异常,进而影响发病进程。在血管平滑肌上以及与其相关的神经末梢表达有多种PKC的亚型,并且大量研究表明PKC的活性与血管收缩密切相关。
作者 高燕 冯秀娥
机构地区 山西医科大学药学院
出处 《山西医科大学学报》 CAS 2016年第5期481-485,共5页 Journal of Shanxi Medical University
基金 国家自然科学基金资助项目(81473100) 山西省自然科学基金资助项目(2013011060-2) 山西医科大学博士启动基金资助项目(B03201213)
关键词 蛋白激酶C 血管收缩 肌球蛋白轻链磷酸酯酶 CA^2+通道
分类号 R337 [医药卫生—人体生理学]
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参考文献36

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二级参考文献17

  • 1Wang L,,Wu B,Sun Y,et al.Translocation of protein kinase Cisoforms is involved in propofol-induced endothelial nitric oxidesynthase activation. British Journal of Anaesthesia . 2010
  • 2Cheng TH,,Chen JJ,Chen CH,et al.Effects of propofol on cyclicstrain-induced endothelin-1 expression in human umbilical veinendothelial cells. Anesthesiology . 2009
  • 3Corcoran TB,O’Shea A,Engel A,et al.The influence of propofolon P-selectin expression and nitric oxide production in re-oxygenatedhuman umbilical vein endothelial cells. Acta Anaesthesiologica Scandinavica . 2006
  • 4Palaniyandi SS,Inaqaki K,Mochly-Rosen D.Mast cells and epsilonPKC:a role in cardiac remodeling in hypertension-induced heartfailure. Journal of Molecular and Cellular Cardiology . 2008
  • 5Sivaraman V,Hausenlov DJ,Kolvekar S,et al.The divergent rolesof protein kinase C epsilon and delta in simulated ischaemia reperfu-sion injury in human myocardium. Journal of Molecular and Cellular Cardiology . 2009
  • 6Sud N,Wedgwood S,Black SM.Protein kinase Cδregulates endo-thelial nitric oxide synthase expression via Akt activation and nitricoxide generation. American Journal of Physiology Lung Cellular and Molecular Physiology . 2008
  • 7Haba M,Kinoshita H,Matsuda N,et al.Beneficial effect of propo-fol on arterial adenosine triphosphate-sensitive K+channel functionimpaired by thromboxane. Anesthesiology . 2009
  • 8Yang M,Ding X,Murray P A.Differential effects of intrave-nous anesthetics on capacitative calciumentry in human pul-monary artery smooth muscle cells. Am J Physiol LungCell Mol Physiol . 2008
  • 9Gragasin FS,Davidge ST.The effects of propofol on vascular func-tion in mesenteric arteries of the aging rat. American Journal of Physiology Heart and Circulatory Physiology . 2009
  • 10Partovian C,Zhuang Z,Moodie K,et al.PKCalpha activateseNOS and increases arterial blood flow in vivo. Circulation Research . 2005

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山西医科大学学报
2016年 第5期

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