过敏进程与干预策略的研究进展

Progress on the allergic march and prevention

过敏性疾病的发生和发展通常遵循一定规律，通过临床研究及对既往的队列研究再分析认为只有7％的患儿遵循既往所认为的由湿疹到哮喘、过敏性鼻炎的发展规律。过敏性疾病的进程由多因素共同作用，可通过某些预防方法来阻止过敏性疾病的发生及发展，包括人乳喂养、其他食物的添加、环境控制、药物治疗等。该文就儿童过敏性疾病的进程及干预展开综述，为临床实际工作中对该疾病的预后及预防干预提供理论依据。

While the term ＂atopic march＂ has been used to imply a natural progression of a cascade of symptoms from eczema to asthma and rhinitis through childhood, this developmental profiles at an individual lev- el are not accurate. Only a small proportion of children （7 % ） follow this profile. There are increasing evidences from longitudinal studies suggesting that there exist other allergic phenotypes. Through the development of inter- nal and external mechanism of allergic disease, we could do something to help earlier diagnosis and facilitate no- vel approaches to disease prevention, such as human breast milk, solid food, environmental control, pharmaco- therapy, etc. This review alms to summarize recently published articles in order to highlight novel research find- ings, clinical trial results and guidelines to assist in identifying prevention strategies to arrest the atopic march.