纳米材料对鼠科动物的生殖毒性及致毒机理

Reproductive Effects and Their Mechanisms of Nanomaterials on Murine

纳米材料是近几年应用越来越多的一种新型材料,因此国内外科研单位对其毒性的研究也逐年增加。但是目前对鼠科动物生殖毒性及其机理的了解还相对较少,亟需大量研究填补此领域的空白。本文主要从亲代和子代2个方面阐述了纳米材料对鼠科动物的生殖毒性,从不同生物水平等方面概述了纳米材料对亲子两代鼠科动物的损伤效应及可能的机制。最后,试探性地提出了今后在纳米材料领域对鼠科动物生殖毒性的研究重点。

Recently,nanomaterials as emerging materials have been applied in various fields,and their potential toxicity has attracted much attention. However,the reproductive effects and their mechanisms of nanomaterials on murine are unclear. Therefore,it is necessary to perform the relevant work to fill the gaps in knowledge. The present review elucidates the reproductive effects of nanomaterials on murine involving parents and offspring,and summarizes the potential mechanisms of toxic effects at different biotic levels. Finally,the future emphases of researches on the reproductive effects of nanomaterials were proposed.