脑胶质瘤组织中Tip60蛋白表达与预后关系

Relationship between Expression of Tip60 Protein in Glioma Tissue and Prognosis

目的揭示脑胶质瘤组织中Tip60蛋白表达与临床病理特征及长期预后的关系。方法收集108例脑胶质瘤肿瘤标本，采用免疫组织化学方法检测神经胶质瘤组织Tip60蛋白表达，统计分析Tip60蛋白表达与患者性别、年龄、组织学分级、肿瘤部位、肿瘤类型、肿瘤直径和KPS评分等临床病理特征及5年总生存时间的关系。结果脑胶质瘤组织中Tip60蛋白表达与肿瘤级别密切相关，高级别胶质瘤比低级别胶质瘤Tip60蛋白表达显著减少（P〈0．001）。Tip60蛋白低表达组患者平均5年总生存时间25．3个月（95％CI：20．9—29．8），Tip60蛋白高表达组患者平均5年总生存时间38．9个月（95％CI：32．9～45．0）；经Log—rank检验，低表达组平均5年总生存时间显著短于高表达组（P=0．001）。多因素COX回归分析显示，Tip60蛋白低表达是5年总生存时间缩短的独立危险因素（HR=1．762，95％CI：1．028～3．020，P=0．039）。结论Tip60蛋白与神经胶质瘤恶性程度密切相关，Tip60蛋白低表达是神经胶质瘤长期预后不良的独立危险因素。

Objective To investigate the relationships between expression of Tip60 protein in glioma tissue and clinicopathological characteristics and long - term prognosis. Methods Totally 108 brain glioma specimens were collected, Expressions of Tip60 protein in glioma tissue were determined using immunohistochemistry. Relationships between expression of Tip60 protein and clinicopathological characteristics of human brain glioma （such as gender, age, histological grade, tumor location, tumor type, tumor size and KPS score） and 5 - year overall survival were analyzed statistically. Results Expressions of Tip60 protein in glioma tissue were closely correlated with histological grade. Expressions of Tip60 protein were markedly lower in high grade glioma than in low grade glioma （ P 〈 0. 001 ）. Mean 5 - year overall survival time of patients with high and low expression of Tip60 protein were 38.9 months （ 95% CI ： 32.9 - 45.0） and 25.3 months （95% CI：20.9 - 29.8 ） respectively and intergroup difference was statistically significant using Log - rank test （ P = 0. 001 ）. Multivariate COX regression analysis showed that low expression of Tip60 protein was an independent risk factor for short 5 - year overall survival time （ HR = 1. 762, 95% CI ： 1. 028 - 3. 020, P = 0. 039）. Conclusion Tip60 protein is closely correlated with malignant behaviors of glioma and low expression of Tip60 protein emerges as an independent risk factor for long - term poor prognosis of glioma.