男性糖尿病患者血清睾酮水平与动脉粥样硬化的相关性

Relationship between Testosterone Levels and Atherosclerosis in the Males with Diabetes

目的研究男性糖尿病患者的血清睾酮(testosterone,T)水平与颈动脉内膜中层厚度(intima-media thickness,IMT)的关系,进而探讨男性糖尿病患者血清雄激素水平与动脉粥样硬化(atherosclerosis,AS)的相关性。方法收集126名男性糖尿病患者,高频超声测量其颈动脉IMT,并根据IMT将患者分为正常组(n=64)和增厚组(n=62),记录患者年龄、并测定其血清睾酮(T)、甘油三酯(triglyceride,TG)、总胆固醇(total cholesterol,TC)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、糖化血红蛋白(glycosylated hemoglobin,Hb A1c)水平。结果 IMT增厚组患者年龄较正常组大(P<0.05),而睾酮水平则降低(P<0.05),其他指标组间差异无统计学意义(P>0.05)。进一步的Logistic回归分析,发现年龄与颈动脉IMT呈正相关,而睾酮水平与颈动脉IMT呈负相关,其中睾酮水平与颈动脉IMT的相关性更大。结论男性糖尿病患者血清睾酮水平的降低可促进动脉粥样硬化(AS)的发生,年龄以及睾酮水平与动脉粥样硬化(AS)的发生存在相关性。

Objective To investigate the correlation between testosterone （T） level and carotid intima - media thickness （IMT） in men with diabetes, and to investigate the influence of testosterone level during the atherosclerosis＇s forming. Methods Totally 126 males with diabetes were distributed to two groups due to the IMT, 64 patients with IMT 〈 0.9mm （normal group） and 62 patients with IMT 〉1 0.9mm （thicker group）. We collected and recorded the patients＇ testosterone （T） , age, triglyceride （TG） , total cholesterol （TC） , high density lipoprotein cholesterol （ HDL - C） , low density lipoprotein cholesterol （ LDL - C） , and glycosylated hemoglobin （ HbA1 c）. Results The discrepancy of age （ r = 0.101, P〈0.01） and testosterone levels（r= -0.305, P〈0.01） between normal group and thic- ker group was significant. Age and T were both the factors of influence to IMT, especially the T level. Conclusion Lower testosterone level in males with diabetes can promote the forming of atherosclerosis. Diabetes, age and the testosterone level are correlates of atheroscle- rosis＇s forming.