贲门癌与非贲门癌根治术后患者的临床病理特点及预后分析

Comparison of Clinicopathological Features and Prognosis of Radical Resection for Cardia Cancer and Non-cardia Cancer

目的探讨贲门癌与非贲门癌根治术后患者的临床病理特点及预后。方法回顾性分析笔者医院2007年8月-2010年3月717例行胃癌根治术患者的临床资料及随访资料，按肿瘤部位分为贲门癌组和非贲门癌组，对两组患者的临床病理特点及预后进行分析。结果与非贲门癌组相比，贲门癌组男性患者、≥60岁者、瘤体最大直径≥4cm者、有神经侵犯者、有脉管内癌栓者、术前白蛋白〈40g／L者、Ⅲ期患者、有淋巴结转移者、浸润深度达T，～T。者所占比例更高，且差异均有统计学意义（P〈0．05），而两组在术后病理分级差异无统计学意义（P〉0．05）。贲门癌根治术后患者的5年生存率为42．0％，明显低于非贲门癌根治术后患者的5年生存率63．2％，差异有统计学意义（P〈0．05）。结论贲门癌与非贲门癌在临床病理方面差异有统计学意义，且根治术后预后比非贲门癌差。

Objective To explore the clinicopathological features and prognosis in cardia cancer and non - cardia cancer that underwent gastric radical resection. Methods A retrospective clinical analysis was made in 717 cases gastric cancer. All the patients were treated by radical resection in Jiangsu province people＇s hospital from Aug 2007 to Mar 2010. According to different tumor position the patients were divided into cardia cancer group and non - cardia cancer group. Results Patients with males, more than 60 years old, tumor max diameter more than 4cm, nerve invasion, vascular tumor embolus, preoperative albumin lower 40g/L, stage Ⅲ （TNM）, lymph node metastasis positive and infiltration depth reached T3 -T4 in cardia cancer group were more common than non - cardia cancer group（P 〈 0.05 ）, but two groups had no significant difference in the pathologic differentiation degrees （P 〉 0.05 ）. The 5 - year survival rate of cardia cancer group was lower than non - cardia cancer group （42.0% vs 63.2% ） （P 〈 0.05）. Conclusion The clinicopathological features of cardia cancer and non - cardia cancer are significantly different, and the prognosis of cardia cancer worse than non - cardia cancer.