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自发性蛛网膜下腔出血的致病机制研究进展

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摘要 自发性蛛网膜下腔出血(subarachnoid hemorrhage,SAH)是一种常见的神经外科急症,严重威胁人类健康和生命。神经血管单元(the neurovascular unit,NVU)是内皮细胞、周细胞、血管平滑肌细胞、神经胶质和神经元所构成的结构单元,它控制血-脑脊液屏障通透性、脑血流量并维持神经系统环境,而神经系统环境是维持神经元正常功能的必要条件。最近的证据表明血-脑脊液屏障功能障碍与脑实质的血管毒性及神经毒性、血脑流量降低及缺氧的联合作用有关。本文主要聚焦蛛网膜下腔出血导致的神经血管功能障碍的机制,特别是蛛网膜下腔出血后早期脑损伤的血-脑脊液屏障破坏的相关机制及其进展,此外探讨相关血管神经损伤治疗机会。
机构地区 哈尔滨医科大学
出处 《医学研究杂志》 2016年第5期174-176,共3页 Journal of Medical Research
基金 国家自然科学基金资助项目(31372268)
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