170株鲍曼不动杆菌的临床分布及耐药性分析

Research on clinical distribution of 170 strains of acinetobacter baumannii and analysis of their drug resistance

目的了解标本中鲍曼不动杆菌的临床分布及耐药特点,对医院感染控制及临床用药提供参考和指导。方法回顾性调查收集该院2014年1月至2015年8月微生物室分离的170株鲍曼不动杆菌,对其感染分布与耐药情况进行分析。结果分离的170株鲍曼不动杆菌,主要分布在重症监护室(ICU)、呼吸内科,标本主要为痰标本;对复方磺胺甲噁唑耐药率最低,对氧氟沙星等其他9种抗菌药物的耐药率均较高。结论鲍曼不动杆菌主要引起呼吸道感染,对现有多种抗菌药物耐药严重;提示临床高度关注该菌,加强对该菌的监测,合理使用抗菌药物,有效控制泛耐药菌的出现和扩散。

Objective To explore the clinical distribution and drug-resistant characteristics of acinetobacter baumannii;and to provide reference and guidance for the infection control and clinical medication.Methods A retrospective investigation was carried out on 170 strains of acinetobacter baumannii isolated from the microorganism laboratory from January 2014 to August 2015.And their infectious distribution and drug resistance were analyzed.Results The 170 strains of acinetobacter baumannii isolated were mostly distributed in the intensive care unit（ICU）and respiratory medicine.The positive specimens were mostly sputum specimens.The drug-resistant rate of sulfamethoxazole was lowest,while which of the other 9antibacterial agents including levofloxacin were relatively higher.Conclusion Acinetobacter baumannii mainly cause respiratory infections and are severely resistant to multiple antimicrobial agents.This finding suggests that clinical doctors should pay highly attention to this kind of bacteria,strengthen the monitoring,and use antimicrobial agents rationally,so as to control the emergence and spread effectively.