常见性病病原体感染的流行趋势与相关性分析

Epidemic trend and correlation analysis of common venereal pathogen infection

目的研究本地区常见性病病原体的流行病学趋势,分析其合并感染的可能相关性。方法实时荧光PCR法检测临床送检标本,化学发光免疫分析法(CMIA)检测梅毒血清抗体。分析各年间病原体的感染流行情况与合并感染的相关性。结果2010年至2014年,共检出解脲支原体2 171例,沙眼衣原体1 195例,淋病奈瑟菌552例,人乳头瘤病毒1 835例,单纯疱疹病毒489例,梅毒抗体阳性816例。发现同一标本内存在感染多种病原体菌现象。解脲支原体、沙眼衣原体与人乳头瘤病毒检出率变化明显,χ2趋势检验分析显示沙眼衣原体与人乳头瘤病毒检出率呈增长趋势(P<0.05)。淋病奈瑟菌、单纯疱疹病毒和梅毒检出率无显著变化。解脲支原体、沙眼衣原体和淋病奈瑟菌合并感染现象严重,Pearson相关显示解脲支原体与沙眼衣原体存在直线相关性(r=0.640,P<0.05)。结论本地区解脲支原体与沙眼衣原体感染趋势日渐严重,积极开展性病防治教育活动,控制隐性性传播疾病合并感染现象。

Objective To explore epidemiological trends of common pathogens of sexually transmitted diseases（STD）in the local area,and to analyze possible correlations with concurrent infection.Methods Real-time fluorescent nucleic acid amplification technology（PCR）was used to detect the pathogens in clinical specimens,chemiluminescence immune analysis method（CMIA）was used to detect syphilis serum antibody.And the relationship between pathogen epidemic situation and concurrent infection were analyzed of these years.Results From 2010 to 2014,Ureaplasma urealyticum was detected in 2 171 cases,and Chlamydia trachomatis in 1 195 cases,Neisseria gonorrhoeae in 552 cases,Human papilloma virus in 1 835 cases,Herpes simplex virus in 489 cases and positive syphilis antibody in 816 cases.The phenomenon of concurrent infection was also found in the same specimen.Differences of detection rate of Ureaplasma urealyticum and Chlamydia trachomatis and human papillomavirus had a statistical significance.Chi square trend test showed that Chlamydia trachomatis and human papillomavirus got a linear growth trend in detection rate（P〈0.05）.Neisseria gonorrhea,herpes simplex virus and syphilis detection rate had no significant change.Concurrent infection phenomenon of Ureaplasma urealyticum complicated with Chlamydia trachomatis and Neisseria gonorrhoeae was serious.Correlation analysis showed that there was a positive correlation between Ureaplasma urealyticum and Chlamydia trachomatis（r=0.640,P〈0.05）.Conclusion Ureaplasma urealyticum and Chlamydia trachomatis infection trend is serious,it′s necessary to actively carry out STD prevention education activities to control sexually transmitted diseases complicated with infections of recessive phenomenon.