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脑源性神经营养因子在氯胺酮抗抑郁中的作用 被引量：4

The role of brain-derived neurotrophic factor in the antidepressant effect of ketamine
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摘要 抑郁症是一种常见的精神类疾病,是自杀的首要原因。氯胺酮作为临床上常用的全身麻醉药亦具有快速、有效的抗抑郁作用,且可快速缓解难治性抑郁患者的自杀倾向。脑源性神经营养因子(brain derived neurotrophic factor,BDNF)是一种广泛表达于中枢神经系统中的神经营养因子,其表达上调被认为是氯胺酮抗抑郁作用的关键步骤。文中综述了BDNF及其下游信号通路在氯胺酮抗抑郁中的作用。 Depression is a common mental disease,which is the leading cause of suicide. Ketamine,a commonly used general anesthetic in clinical practice,exerts a rapid and effective antidepressant effect,and reduces suicide ideation in patients with treatmentresistant depression quickly. Brain-derived neurotrophic factor（ BDNF） is a neurotrophic factor widely expressed in central nervous system,the increase of which has been shown to be critical in the antidepressant effect of ketamine. This article aims to review the role of BDNF and its downstream signaling pathways in the antidepressant effect of ketamine.
作者 王菁 张广芬(综述) 杨建军 周志强(审校)
机构地区 南京大学医学院附属金陵医院(南京军区南京总医院)麻醉科
出处 《医学研究生学报》 CAS 北大核心 2016年第5期538-541,共4页 Journal of Medical Postgraduates
基金 国家自然科学基金(81503053,81571083)
关键词 氯胺酮 抑郁症 脑源性神经营养因子 雷帕霉素靶蛋白 糖原合成酶激酶-3 Ketamine Depression Brain-derived neurotrophic factor Mammalian target of rapamycin Glycogen synthase kinase 3
分类号 R749.99 [医药卫生—神经病学与精神病学]
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参考文献35

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  • 2王睿,黄树明.抑郁症发病机制研究进展[J].医学研究生学报,2014,27(12):1332-1336. 被引量：137
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二级参考文献89

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共引文献148

同被引文献25

引证文献4

二级引证文献9

医学研究生学报
2016年 第5期

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