贲门癌中CyclinD1蛋白的表达及意义

Expression and Clinical Significance of CyclinD1 Protein in Cardia Cancer

目的促进贲门癌的诊断和治疗,探讨CyclinD1在贲门癌中的表达及意义。方法收集32例贲门癌和配对的癌旁组织标本,用免疫组化的方法检测贲门癌组织及其配对的癌旁组织中CyclinD1蛋白的表达水平,分析该蛋白与贲门癌临床病理的相关性,并评价CyclinD1蛋白的临床意义。结果贲门癌组织中CyclinD1阳性表达为84.8%(27/32)高于癌旁组织的40.6%(13/32),差异有统计学意义(P<0.05),且与贲门癌临床分期相关(P<0.05),而与性别、年龄、肿瘤分化程度和转移等无关。CyclinD1在个临床分期≥Ⅲ_b的阳性表达为70.6%(12/17),在临床分期<Ⅲ_b的阳性表达为26.7%(4/15),差异有统计学意义(P<0.05)。结论 CyclinD1贲门癌组织中表达上调,且与临床分期相关,CyclinD1在贲门癌的发展过程中可能具有一定促进作用。

Objective To investigate the expression and its clinical significance of CyclinD1 in gastric cardia adenocarcinoma（GCA）. Methods The immunohistochemistry was used to determine the level of CyclinD1 in 32 cases of GCA tissues and its adjacent non-cancerous tissues.we also analyzed the correlation between the CyclinD1 and cardia cancer clinicopathologic characteristics,and evaluated the its clinical significance of CyclinD1 protein in cardia cancer. Results The immunohistochemistry results showed that the positive rate of CyclinD1 protein was 84.4%（27 /32）in GCA and 40.6%（13 /32）in its adjacent non-cancerous tissues respectively, which was significantly statistic difference （P 〈0.05 ）. The CyclinD1 expression in GCA showed a significant correlation to TNM-staging （P 〈0.05）,but no correlation was found in age,gender,tumor differentiation degree and lymph node metastasis.The positive rate were 70.6%（12 /17）in the TNM stage ≥Ⅲ b and 26.7%（4 /15）in the TNM stage 〈Ⅲ b （P 〉0.05 ）. Conclusion The expression of CyclinD1 was significantly higher in GCA and had correlation to clinic stage of GCA.The CyclinD1 protein may play an important role in the development of GCA.