金英胶囊镇痛抗炎作用实验研究

Experimental Study on Analgesic and Anti-Inflammatory Effects of Jinying Capsule(金英胶囊)

目的:研究金英胶囊镇痛和抗炎药理作用。方法:采用小鼠扭体法和热板法镇痛实验,研究金英胶囊的镇痛作用,用二甲苯致小鼠耳廓炎症、醋酸致小鼠腹腔毛细血管通透性改变及大鼠棉球肉芽肿的方法,对金英胶囊进行抗炎实验。结果:金英胶囊能显著提高小鼠对热致痛反应的阈值和减少醋酸致小鼠扭体次数,能显著抑制二甲苯致小鼠耳廓肿胀,显著降低毛细血管的通透性,显著减轻大鼠棉球肉芽肿的重量。结论:金英胶囊具有明显的镇痛抗炎作用。

Objective： To study the analgesic and anti-inflammatory pharmacological effects of Jinying cap- sule. Methods： The analgesic effect was observed with the response of writhes and hot plate test.The anti-in- flammatory effect was observed by mice inflammation models caused by xylene, mice models with reinforce per- meability of abdominal cavity capillary caused by acetic acid and rats granuloma models with cotton ball. Re- sults： The Jinying capsule can improve the mice to thermal stimulation pain threshold and reduce the number of mice body twisting with acetic acid, also can inhibit the mouse ear swelling caused by xylene, reduce the cap- illary permeability significantly, and reduce the granuloma weight of rats by cotton ball. Conclusion： The Jinying capsule shows a significant analgesic and anti-inflammatory effects.