热毒宁注射液治疗小儿轮状病毒肠炎的Meta分析

Meta Analysis on the Treating Rotavirus Enteritis by Reduning Injection(热毒宁注射液) in Children

目的:系统评价热毒宁注射液治疗轮状病毒肠炎的有效性和临床优越性。方法:计算机检索维普资讯中文科技期刊数据库(VIP,1989年)、中国生物医学文献数据库(CBM,1979年)、中国期刊全文数据库(CNKI,1990年)、万方数据库(1990年)。对符合纳入标准研究文献进行质量评价,并提取有效数据,采用Rev Man 5.3软件对纳入的文献进行异质性检验和效应值的合并,同时进行各文献的发表偏倚的评估,最后给出Meta分析结果的森林图和漏斗图。结果:检索到符合纳入标准的文献6篇,治疗组373例,对照组364例。Meta分析结果显示:治疗组的总有效率明显优于对照组(合并OR=4.29,其95%CI为[2.73,6.73],合并效应量的检验Z=6.33,P<0.05),治疗组的腹泻症状恢复时间少于对照组(合并WMD=-1.01,其95%CI为[-1.38,-0.65],合并效应量的检验Z=5.49,P<0.05),具有显著统计学意义。结论:热毒宁注射液治疗小儿秋季腹泻的疗效优于利巴韦林治疗,可缩短腹泻时间。

Objective： To evaluate the clinical effect and advantage of Reduning injection on rotavirus enteritis. Methods： Meta-analysis was used to evaluate the data extracted from published papers on the VIP （1989）, CBM （1979）, CNKI （1990） and Wanfang Data （1990）. The research literature meeting the inclusion cri- teria were evaluated and effective data was extracted. The Cochrane Collaboration＇s RevMan 5.3 software was used for Meta analysis, with heterogeneity test and consolidation of effect values. The publication bias was evaluated; There were forest map and funnel plot from the Meta analysis. Results： A total of 6 RCTs were involved, with 373 patients in treatment group and 364 patients in control group. According to the results of Meta analysis, the treatment group showed higher total effective rate than control group （OR=4.29, 95%CI[2.73,6.73], Z= 6.33, P〈0.05）. The treatment group showed shorter recovery time of diarrhea than the control group （WMD=-1.01, =95%CI [-1.38,-0.65], Z=5.49, P〈0.05）, with statistical difference. Conclusion： Reduning injection showed better efficacy than the ribavirin on autumn diarrhea in children, with effect of reducing the time of diarrhea.