肾衰宁颗粒联合羟苯磺酸钙对慢性肾脏病疗效的观察

Effects of Shenshuaining granules and calcium dobesilate on the chronic kidney disease

目的 慢性肾脏病（CKD）如未能得到及时有效治疗,呈持续进行性发展,最终进入到终末期肾衰竭（ESRD）则需长期肾脏替代治疗。羟苯磺酸钙最早用于糖尿病视网膜病变,后发现对糖尿病肾病、慢性肾功能不全亦有效,肾衰宁颗粒常用于各种原因所致的肾功能不全患者,为更好地延缓肾功能进展,本研究采用羟苯磺酸钙联合肾衰宁颗粒治疗,观察其对肾功能的影响。方法 选择慢性肾炎引起的慢性肾脏病3～4期的患者120例作为研究对象,随机分为3组,羟苯磺酸钙组40例,肾衰宁组38例,联合治疗组42例。羟苯磺酸钙组：采用羟苯磺酸钙组胶囊500 mg,每日2次口服;肾衰宁组：采用肾衰宁颗粒1包,3次/d;联合治疗组：上述两药联合治疗。3组疗程均为8周。观察治疗前、治疗后4周、8周肾功能和肾小球滤过率等的变化。应用SPSS 20.0统计软件进行分析。结果 3组治疗前BUN、Cr、e GFR差异均无统计学意义;3组治疗后4周、8周与治疗前比BUN、Cr下降,e GFR上升,有统计学意义（P〈0.01）。联合治疗组与羟苯磺酸钙组比,治疗后4周、8周BUN、Cr下降,e GFR上升（P〈0.05）。联合治疗组与肾衰宁组比,治疗后4周、8周BUN下降,e GFR上升（P〈0.05）;治疗后8周Cr下降（P〈0.05）。结论 单独使用羟苯磺酸钙、肾衰宁颗粒均能改善慢性肾脏疾病3、4期患者肾功能,但上述两药联合治疗对改善慢性肾脏疾病3、4期患者肾功能更显著。

Objective CKD failed to get timely and effective treatment, and ultimately into the end of end-stage renal fail- ure will require long-term renal replacement therapy. Calcium dobesilate was first used in diabetic retinopathy, and it was found to be effective for diabetic nephropathy. Renal Failure Granules used to renal insufficiency patients caused by vari- ous reasons. To observe the effects of Renal Failure Granules and calcium dobesilate on the chronic kidney disease. Meth- ods One hundred and twenty patients with stage 3 -4 CKD caused by primary chronic glomerulonephritis were put into three groups including 40 patients taking calcium dobesilate. Thirty-eight patients took Renal Failure Granules and 42 pa- tients took Renal Failure Granules and calcium dobesilate. The patients took 500 mg of calcium dohesilate two times a day, one pack of Renal Failure Granules three times a day. day. Then observe the levels of serum creatinine（Cr）. Urea ni- trogen（BUN） and glomerular fihration rate（GFR） before treatment and after four weeks of treatment and eight weeks of treatment. Results ①Cr, eGFR, and BUN were not significantly different in the 3 groups before treatment, the Cr and BUN were decreased after 4 weeks, 8 weeks after treatment, and eGFR was increased, and it was statistically significant （P 〈 0.01 ）. ②Compared with the combined treatment group and calcium dobesilate group, the Cr and BUN in the com- bined treatment group were decreased after 4 weeks, 8 weeks after treatment, and eGFR was increased, and it was statisti- cally significant（P 〈 0.05）.③Compared with the combined treatment group and Renal Failure Granules group,the BUN in the combined treatment group were decreased and eGFR was increased after 4 weeks, 8 weeks after treatment, and it was statistically significant （ P 〈 0. 05 ）. The Cr in the combined treatment group was decreased after 8 weeks. Conclusion Separate use of calcium dobesilate and renal failure granules can improve renal function of patients with stage 3 -4 CKD, but the two drug combination therapy is more significant.