T细胞亚群和白细胞介素36在系统性红斑狼疮发病机制中的研究进展

T cell subsets and interleukin-36 in the pathogenesis of systemic lupus erythematosus

在不同的细胞因子环境下,原始T细胞分化生成的Th1、Th2、Th17及Treg等细胞构成的细胞亚群及其细胞因子在系统性红斑狼疮等自身免疫性疾病的发病中发挥重要作用.白细胞介素36包括白细胞介素36α、363和36 γ,其免疫调节及免疫激活作用较传统白细胞介素1家族成员更强,通过激活丝裂原活化蛋白激酶和核因子κB,参与自身免疫性疾病的生理病理过程.白细胞介素36对T细胞分化的研究能进一步阐明系统性红斑狼疮的发病机制,为系统性红斑狼疮的治疗策略提供思路.

Under the effect of different cytokines,naive T cells can differentiate into multiple cell subsets,including Th1,Th2,Th17,Treg cells,and so on.These T cell subsets and their cytokines play important roles in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus （SLE）.Interleukin-36 （IL-36）,including IL-36α,IL-36β and IL-36γ shows stronger immunoregulatory and immunoactivation effects than traditional IL-1 family members,and participates in the pathophysiological process of autoimmune diseases by activating the mitogenactivated protein kinase and nuclear factor kappa-B.To investigate the effect of IL-36 on differentiation of T cells may facilitate the clarification of SLE pathogenesis,and provide new ideas to its treatment.