SOX7及其在肿瘤中的表达和作用

SOX7 and its expression and function in tumors

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摘要 SOX7是转录因子SOX家族成员，调控多种生物学过程。研究发现SOX7基因是一个抑癌基因，其表达在绝大多肿瘤中下调，可能是通过调节Wnt—β-连环蛋白信号通路介导的转录过程抑制肿瘤的增殖、迁移和侵袭等生物学行为，在肿瘤的发生中起着重要作用。 SOX7 belongs to the SOX gene family. And it has been shown to regulate multiple biological processes. Studies have found that SOX7 gene is likely to be a tumor suppressor gene. In many tumors, SOX7 downregulation that inhibits proliferation, migration and invation of tumor via regulating the Wnt-β-catenin signaling pathway mediated the transcription process, which plays a significant role in tumorigenesis.

作者何会萍徐祖敏官成浓

机构地区广东医学院附属医院肿瘤科

出处《国际肿瘤学杂志》 CAS 2016年第4期271-273,共3页 Journal of International Oncology

关键词转录因子基因肿瘤抑制 SOX7 Transcription factors Genes, tumor suppressor SOX7

分类号 R730.2 [医药卫生—肿瘤]

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参考文献22

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国际肿瘤学杂志

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SOX7及其在肿瘤中的表达和作用

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