探析二甲双胍对糖尿病前期的干预效果

Invesitgation of intevention effect by metformin for prediabetic phase

目的探究二甲双胍对糖尿病前期干预的疗效及安全性。方法 58例糖尿病前期患者,随机分为治疗组和对照组,各29例。两组均进行生活方式干预,治疗组在此基础上加服二甲双胍片,比较两组治疗效果和糖尿病发病率,观察治疗组的不良反应。结果两组治疗后空腹血糖(FPG)及餐后2小时血糖(2 h PG)均有所下降,治疗组下降更明显,差异均具有统计学意义(P<0.05);治疗组糖尿病发病率明显低于对照组(P<0.01);治疗组共8例患者出现胃肠道反应。结论二甲双胍可以有效降低糖尿病前期的血糖水平,同时可以显著降低糖尿病的发病率,不良反应发生率较低。

Objective To investigate curative effect and safety by metformin for prediabetic phase. Methods A total of 58 patients in prediabetic phase were randomly divided into treatment group and control group, with 29 cases in each group. Both groups received lifestyle intervention, and the treatment group also received additional metformin tablets. Comparison was made on curative effects and incidence of diabetes mellitus between the two groups. Adverse reactions in the treatment group were observed. Results After treatment, both groups had decreased fasting plasma glucose（FPG） and 2 h postprandial blood glucose（2 h PG）, and the treatment group had more obvious decrease than the control group. Their differences all had statistical signficance（P〈0.05）. The treatment group had much lower morbidity of diabetes mellitus than the control group（P〈0.01）, and it had 8 cases with gastrointestinal reaction. Conclusion Metformin can effectively reduce blood glucose level in prediabetic phase and morbidity of diabetes mellitus, with low incidence of adverse reactions.