摘要
目的探讨中国人群中IGF-1和IGFBP-3多态性与前列腺癌易感性的相关性。方法采用以医院为基础的病例对照研究模式,应用Taq Man探针法对IGF-1和IGFBP-3的9个SNPs进行基因分型,检测664例患者和702例对照者的基因型,分层分析与前列腺癌发生有关的可能因素。结果前列腺癌组和对照组进行比较时,rs6218,rs35767和rs5742612的基因型和等位基因频率分布存在显著差异（P=0.005、0.005和0.020）。在综合分析中,具有2~6个风险等位基因的个体患前列腺癌的风险显著高于具有0~1个风险等位基因的个体。研究还发现,组合风险等位基因与前列腺癌风险之间的关联主要表现在以下几组：年龄〉71岁（OR=1.41,95%CI=1.05~1.91,P=0.020）,不吸烟（OR=1.68,95%CI=1.21~2.32,P=0.002）,不喝酒（OR=1.32,95%CI=1.02~1.61,P=0.002）,前列腺癌家族史（OR=1.28,95%CI=1.02~1.71,P=0.022）。结论在中国人群中,3个单核苷酸多态性（rs6218,rs35767和rs5742612）和具有2~6个风险等位基因的联合基因型可能与前列腺癌的易感性相关,而与前列腺癌的进展无关。
Objective To investigate the association between the functional polymorphisms in IGF-1 and IGFBP-3 and the risk of prostate cancer（ PCa） in the Chinese population. Methods We obtained information on demographic factors by a personal interview. This hospital-based case-control study included 664 PCa patients and 702 cancer-free controls. Nine SNPs in IGF-1 and IGFBP-3 were genotyped using the TaqM an assay.Results The genotype and allele frequency distribution of rs6218,rs35767 and rs5742612 were significantly different when comparing PCa cases to controls（ P = 0. 005,0. 005 and 0. 020,respectively）. In the combined analysis,individuals with 2 ~ 6 risk alleles had an elevated risk of PCa compared to those with 0 ~ 1 risk alleles. We also found that the association between the combined risk alleles and the risk of PCa appeared stronger in the following subgroups： individuals older than 71 years of age（ OR = 1. 41,95% CI = 1. 05 ~ 1. 91,P =0. 020）,nonsmokers（ OR = 1. 68,95% CI = 1. 21 ~ 2. 32,P = 0. 002）,nondrinkers（ OR = 1. 32,95% CI =1. 02 ~ 1. 61,P = 0. 002）,and those with a negative family history of PCa（ OR = 1. 28,95% CI = 1. 02 ~ 1. 71,P = 0. 022）. Conclusions The three SNPs（ rs6218,rs35767 and rs5742612） and the joint genotypes with 2 ~ 6risk alleles,may contribute to the susceptibility to PCa,but not the progression,in the Chinese population.
出处
《中国肿瘤外科杂志》
CAS
2016年第2期84-90,95,共8页
Chinese Journal of Surgical Oncology
基金
吴阶平基金资助项目(320.6750.13116)
