白芍总苷对糜烂型口腔扁平苔藓患者外周血中IFN-γ及IL-10表达的影响研究

Influence of Total Glucosides Paeony on the Expression of IFN-γand IL-10 in Peripheral Blood of Patients with Oral Lichen Planus

目的：探讨白芍总苷对糜烂型口腔扁平苔藓患者外周血中IFN-γ及IL-10表达的影响。方法：选取于2014年2月~2015年3月我院皮肤科与口腔科收治的38例糜烂型口腔扁平苔藓患者为研究对象,随机分为对照组和研究组两组。对照组患者,18例,对照组患者,在清除患者口腔中残根、残冠以及牙石等,用0.1%的他克莫司软膏进行局部治疗,2次/d。研究组患者,20例,在对照组治疗的基础上采用口服白芍总苷胶囊进行治疗,比较两组患者一个疗程后的临床疗效,并采用ELISA法检测并比较治疗前后两组患者外周血中IFN-γ及IL-10的表达情况。结果：对照组,18例,其中有效者2例,好转者6例,无效者10例,总有效率为44.4%。研究组,20例,其中其中有效者8例,好转者7例,无效者5例,总有效率为75%。与对照组相比,研究组患者的总有效率显著升高,差异显著（P〈0.05）。治疗后研究组患者外周血中IFN-γ及IL-10的表达水平均显著升高,差异显著（P〈0.05）,具有统计学意义。结论：白芍总苷治疗糜烂型口腔扁平苔藓具有较好的临床疗效,值得临床推广应用。同时,白芍总苷较好的临床疗效可能与其增高了患者外周血中IFN-γ水平及IL-10水平有关。

Objective：To explore the influence of total glucosides of paeony（TGP）on the expression of IFN-γand IL-10 in peripheral blood of patients with oral lichen planus（OLP）.Methods：38patients with OLP were randomly divided into control group and research group.There were 18 patients in the control group,who were extracted the residual roots and residual crowns,and used 0.1% tacrolimus ointment for topical treatment.There were 20 patients in the research group,who were administrated with TGP capsules besides the treatment of control group.The clinical curative effect was compared.The expression of IFN-γand IL-10 in the peripheral blood between two groups of patients was also compared before and after treatment.Results：Compared with control group（44.4%）,the total effective rate of research group（75%）was significantly increased.After treatment,the expressions of IFN-γand IL-10 in the research group were significantly increased.Conclusion：TGP treatment of OLP has good clinical curative effect,which may associate with the increased IFN-γand IL-10 in the peripheral blood of patients.