消渴浴足方治疗糖尿病周围神经病变临床研究

Clinical effect analysis of Xiaoke-Yuzu decoction on diabetic peripheral neuropathy

目的评价消渴浴足方治疗糖尿病周围神经病变（diabetic peripheral neuropathy,DPN）的临床疗效。方法将符合入选标准的100例DPN住院患者按随机数字表法分为2组各50例，对照组采用西医常规治疗，治疗组在此基础上配合消渴浴足方足浴。对2组治疗前后中医症状积分、DPN临床评分（多伦多积分）进行比较，评价临床疗效。结果治疗后，治疗组多伦多评分中，症状分[（1．50±0．94）分比（2．23±1．01）分，t=-2．920]、反射分[（3．60±1．77）分比（4．27±1．72）分，t=-1．980]、感觉分[（1．53±0．63）分比（2．10±0．84）分，t=-2．950]均显著低于对照组（P〈0．05）；治疗组中医证候主症积分[（1．77±1．17）分比（3．17±1．82）分，t=-3．550]、次症积分[（2．23±1．59）分比（4．27±1．57）分，t＝-4．980]、舌苔脉象积分[（1．83±0．65）分比（2．47±0．51）分，t=-4．220]均显著低于对照组（P〈0．01）。结论消渴浴足方可改善DPN患者的临床症状。

Objective To observe the clinical effect of Xiaoke-Yuzu decoction on diabetic peripheral neuropathy （DPN）. Methods A total of 100 DPN inpatients were recruited and randomly divided into the treatment and control groups. The two groups were both received basic therapy, while the treatment group additionally received Xiaoke-Yuzu decoction. Toronto clinical scores and Chinese medicine symptom scores of both groups were collected to evaluate the clinical effect before and after the therapy. Results The Toronto scores of treatment group were significantly lower than control group after treatment （symptoms score 1.50 ± 0.94 vs. 2,23±1.01, reflection score 3.60 ± 1.77 vs. 4.27 ± 1.72, feeling test score 1.53 ± 0.63 vs. 2.10±0.84, all P〈0.05）. Meanwhile, the Chinese medicine symptom scores of treatment group were also significantly lower than the control group （main symptom score 1.77±1.17 vs. 3.17 ±1.82, posterior symptom score 2.23±1.59 vs. 4.27 ±1.57, the tongue and pulse score 1.83 ± 0.65 vs. 2.47 ± 0.51, all P〈0.05）. Conclusion Xiaoke-Yuzu decoction plus basic therpy could improve the clinical symptoms of DPN patients.