乳腺癌基因在基底细胞型乳腺癌中的表达及临床意义

Expression of breast cancer 1 in basal-like breast carcinoma and its significance

目的分析乳腺癌基因(BRCA1)在含基底细胞型乳腺癌组织中的表达,并探讨与其预后因素之间的相关性,了解BRCA1对于患者预后的判断价值。方法回顾性分析142例乳腺癌患者的病历资料,66例确诊的三阴性乳腺癌患者为试验组,其他76例患者为对照组。用免疫组化法检测2组患者肿瘤组织中BRCA1的表达,分析BRCA1在试验组和对照组的表达情况、与基底细胞型乳腺癌临床病理特征之间的关系、与p53和Ki67表达的关系。结果 BRCA1在试验组的阳性表达率为72.70%(48/66),显著高于对照组的55.26%(42/76,P<0.05)。BRCA1与年龄、淋巴结转移情况、组织学分级有关(P<0.05),与民族、肿瘤大小、绝经情况无相关性(P>0.05),其与预后因素p53、Ki67之间存在正相关(P<0.05)。结论 BRCA1是反映肿瘤恶性程度的良好指标,其可作为判断基底细胞型乳腺癌预后的指标,为临床个体化治疗提供依据及新的治疗方向。

Objective To analyze the expression of breast cancer 1（ BRCA1） in breast cancer basal cell-containing tissues and to explore the correlation between their prognostic factors,in order to determine the value for BRCA1 prognosis.Methods A total of 142 cases of breast cancer patients,66 cases diagnosed with triple negative breast cancer patients as treatment group,76 other patients were in control group.Detected the expression of BRCA1 by immunohistochemistry in two groups,and analyzed the expression in treatment group and control group,the relationship between basal cell carcinoma breast cancer and the clinical pathological features,the relationship between p53 and Ki67 expression also obserived.The positive rate of BRCA1 expression in treatment group was 72.70%（ 48 /66）,significantly higher than 55.26%in control group（ 42 /76,P〈0.05）.BRCA1 had positive correlation with age,lymph node metastasis,histological grade（ P〈0.05）,and had no correlation with nation,tumor size,menopausal status（ P〉0.05）,had positive correlation with prognostic factors p53,and Ki67（ P〈0.05）.Conclusion BRCA1 is a good indicator of the degree of malignancy,which could be used as basal cell type breast cancer prognosis,and provide the basis for new therapeutic directions for clinical individualized treatment.