骨胶原肽对老年人骨密度和骨代谢指标的影响

EFFECTS OF BONE COLLAGEN PEPTIDE ON BONE MINERAL DENSITY AND BONE METABOLIC INDICES IN THE ELDERLY

目的观察老年人在服用骨胶原肽后骨密度及骨代谢指标的变化,并初步探讨骨胶原肽的作用机制。方法随机抽取在山东中医药大学第二附属医院健康体检中心体检的社区老年人185例,按骨质疏松症诊断标准,分成骨质疏松症组(OP组)和非骨质疏松症组(非OP组),进行自身前后对照及平行对照试验研究,并根据性别分层。研究对象每日食用海洋鱼骨胶肽粉(每日一次,每次6 g),干预期一年。于干预前后采集老年人桡骨远端骨质信息,测定其甲状旁腺激素(PTH)、血清碱性磷酸酶(ALP)、血清钙(Ca)和血清磷(P)的水平。结果经过一年的干预,男性OP组平均ALP下降了12.67 U/L(P<0.05),平均血清钙升高了0.03mmol/L(P>0.05);非OP组平均ALP下降了9.14 U/L(P<0.05),平均血清钙升高了0.03mmol/L(P<0.05)。女性OP组干预后平均ALP下降了4.96U/L(P<0.05);非OP组干预后平均血清钙上升了0.03mmol/L,平均ALP下降了9.45 U/L,平均PTH下降了6.74 pg/ml,差异均具有统计学意义(P<0.05)。无论男性还是女性,OP组和非OP组干预后骨密度T值均显著升高(P<0.05)。两组相比,差异不具有统计学意义(P>0.05)。结论骨胶原肽可有效改善老年人骨质状况,使骨代谢趋于正向平衡。

Objective To obsevve the changes of bone metabolic parameters and bone mineral density after bone collagen peptide supplementation in the elderly and explore its mechanisms. Methods A total of 185 senior citizens were selected randomly into the study from the medical examination centre of the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine. All the subjects were divided into osteoporosis group（OP group） and non-osteoporosis group（non-OP group） by the diagnostic criteria of osteoporosis to make an autonomous control and parallel control study. The subjects were given collagen peptide（once a day, 6 g per day） for one year. The level of parathyroid hormone（PTH）, serum alkaline phosphatase（ALP）, serum calcium（Ca） and serum phosphorus（P） from distal radius bone were measured before and after the intervention. Results After one year＇s intervention, for male, the average ALP levels of OP group reduced by 12.67U/L（P〈0.05）, while the average level of serum calcium（Ca） increased by 0.03 mmol/L（P〈0.05）. Average reduction in ALP was 9.14U/L（P〈0.05） and the average level of serum calcium（Ca） increased by 0.03 mmol/L（P〈0.05） in Non-OP group. For female, the average ALP levels reduced by 4.96U/L（P〈0.05） in OP group. The average level of serum calcium（Ca） increased by 0.03mmol/L, average ALP and PTH decreased by 9.45 U/L and 6.74 pg/ml respectively in the non-OP group. The differences were statistically significant（P〈0.05）. Notably, the T-score value of bone mineral density（BMD） was increased significantly（P〈0.05） after the intervention regardless of gender difference in OP group and Non-OP group. There were no statistically significant differences between two groups（P〉0.05）. Conclusion The supplementation of bone collagen peptide could improve osseous condition and maintain positive bone balance in the elderly.