124例干燥综合征合并肺间质病变患者的临床分析

Clinical Analysis of 124 Patients with Sjögren Syndrome Associated with Interstitial Lung Disease

目的探讨干燥综合征(SS)合并肺间质病变(ILD)患者的临床特点。方法回顾性分析124例SS患者的临床资料,其中ILD组51例,无ILD组73例,对其临床表现及实验室检验指标等进行分析。结果 SS患者ILD的发生率为41.13%,ILD组患者的平均年龄高于无ILD组。ILD组雷诺现象、呼吸道症状、发热、血清γ-球蛋白升高、免疫球蛋白升高、炎性指标升高的发生率均高于无ILD组(P<0.05)。结论 SS患者中,高龄,出现发热、呼吸道症状或雷诺现象,γ-球蛋白、免疫球蛋白升高,C反应蛋白、红细胞沉降率升高均可提示ILD的可能,为ILD的危险因素。

Objective To investigate the clinical characteristics of Sj？gren syndrome（SS）patients combined with interstitial lung disease（ILD）.Methods The medical records of clinical manifestation and laboratory tests from 124 SS patients were retrospective analyzed,of which 51 patients were diagnosed with ILD and 73 patients without ILD. Results The incidence of ILD in SS patients was 41.13%. The average age of onset was later in SS with ILD than that in SS without ILD. The Raynaud′s phenomenon,fever and respiratory clinical manifestations were more common in SS with ILD than that in SS without ILD.Compared with patients without ILD,patients with ILD had significantly higher level of γ-globulin,immunoglobulin and inflammatory markers（P〈0.05）. Conclusion The advanced age,Raynaud′s phenomenon,fever or respiratory clinical manifestations,higher level of γ-globulin,immunoglobulin,C-reactive protein and erythrocyte sedimentation rate in SS patients may suggest complication with ILD. Those were the risk factors for ILD.