游离脂肪酸、同型半胱氨酸和超敏C反应蛋白与冠状动脉病变的相关性被引量：7

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摘要目的探讨游离脂肪酸(FFA)、同型半胱氨酸(Hcy)和超敏C反应蛋白(hs-CRP)与冠状动脉病变的相关性。方法选择125例具备完整冠状动脉造影资料及生化检查指标的患者作为研究对象,根据冠状动脉造影结果判断其冠状动脉病变程度,其中,冠心病(CHD)组76例,非CHD组49例,并抽血检测其FFA、Hcy和hsCRP的水平。结果 CHD组患者FFA、Hcy和hs-CRP水平较非CHD组患者明显升高(P<0.05),且随着冠状动脉病变支数的增加,FFA、Hcy和hs-CRP水平也随着提高(P<0.05)。同时,随着年龄的增长,Hcy水平也逐渐提高,但FFA及hs-CRP水平却没有明显变化。结论 FFA、Hcy和hs-CRP与冠状动脉病变存在明显的相关性。

作者林育辉何晓青

机构地区广州医科大学附属第三医院心血管内科

出处《广东医学》 CAS 北大核心 2016年第10期1516-1517,共2页 Guangdong Medical Journal

基金广州医科大学科研项目(编号:2013A19) 广州医科大学附属第三医院精英人才计划项目

关键词冠心病游离脂肪酸同型半胱氨酸超敏C反应蛋白

分类号 R541.4 [医药卫生—心血管疾病]

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1Muller C, Gardemann A, Keilhoff G, et al. Prevention of free fat- ty acid - induced lipid accumulation, oxidative stress, and cell death in primary hepatocyte cultures by a Gynostemma pentaphyl- lum extract[ J]. Phytomedieine, 2012, 19(5) : 395 -401.
2李春,李宏亮,余叶蓉,张祥迅.高游离脂肪酸致内皮细胞eNOS活性降低与PKC通路的关系[J].四川大学学报（医学版）,2010,41(2):208-211. 被引量：7
3邬碧波,张黎明,梅长林,唐琦,芦怡舟.慢性肾脏病患者游离脂肪酸与细胞因子及颈动脉病变的关系[J].中华内科杂志,2010,49(7):572-576. 被引量：7
4Jeon SB, Kang DW, Kim JS, et al. Homocysteine, small - vessel disease, and atherosclerosis : an MRI study of 825 stroke patients [J]. Neurology, 2014, 83(8): 695-701.
5Ozkan C, Altinova AE, Cerit ET, et al. Markers of early athero- sclerosis, oxidative stress and inflammation in patients with acro- megaly[J]. Pituitary, 2015, 18(5): 621 -629.

二级参考文献15

1余叶蓉.胰岛素抵抗状态下高游离脂肪酸血症对血管内皮细胞功能的影响[J].中华糖尿病杂志（1006-6187）,2005,13(4):313-315. 被引量：8
2张文杰,史英钦,宋光耀,王智华,张咏梅.不同的脂肪酸对人血管内皮细胞增殖和凋亡的影响[J].中国老年学杂志,2005,25(11):1312-1314. 被引量：7
3苏进,刘瑞,杨波,田浩明.葡萄糖及游离脂肪酸对人血管内皮细胞凋亡的影响[J].生物医学工程学杂志,2006,23(1):170-174. 被引量：7
4lchiro C, Miehio S, Ken Y, et al. Lipotoxieity: endothelial dysfunction via fatty-acid-induced reactive oxygen species overproduction in obese zucker diabetic fatty rats. Endocrinology, 2007 , 148(1) : 160-165.
5Steinberg HO, Paradisi G, Hook G, et al. Free fatty acid elevation impairs insulin-mediated vasodilation and nitric oxide produetion. Diabetes,2000.49(5), 1231-1238.
6Zoltan U, Anna C, An H, et al. Wolin and akos koller high pressure induces superoxide production in isolated arteries via protein kinase C-dependent activation of NAD(P)H oxidase. Circulation, 2003. 108(8). 1253-1258.
7Clerk LH, Rattigan S, Clark MG. Lipid infusion impairs physiologic insulin-mediated capillary recruitment and muscle glucose uptake in vivo. Diabetes,2002,51(3) : 1138-1145.
8Newton AC. Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. Biochem, 2003,370(3) :361-371.
9Itani SI, Ruderman NB, Schmieder F, et al. Lipid induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C and IκB-a. Diabetes, 2002. 51 (7).2005-2011.
10Griffin ME, Marcucci MJ, Cline GW, et al. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C and alterations in the insulin signaling cascade. Diabetes, 1999 . 48(5) : 1270-1274.