期刊文献+

异质性胞核核糖核蛋白与肺癌发生发展的关系

下载PDF
导出
摘要 肺癌发生于支气管黏膜上皮,亦称支气管癌。近50年来许多国家都报道肺癌的发病率明显升高,在男性癌症患者中,肺癌已居首位,在发达国家31%的男性癌症患者死于肺癌:女性发病率也迅速升高,25%的女性癌症患者死于肺癌,甚至超过乳腺癌。目前,对于肺癌的筛查仍然没有一种确切的方法,胸透和痰细胞学很常用,但是敏感度不高。随着基因组学和蛋白质组学研究的迅猛进展,分子靶向标记在肺癌的早期检测中起着越来越重要的作用。
作者 韩姣 曾凡军
出处 《广东医学》 CAS 北大核心 2016年第10期1578-1580,共3页 Guangdong Medical Journal
基金 湖北省卫生计生西医类一般项目(编号:WJ2015MB260)
  • 相关文献

参考文献23

  • 1Alberts WM, Bepler G, Hazehon T, et al. Lung cancer. Practice organization[J]. Chest, 2003, 123(1 Suppl) : 332S-337S.
  • 2Spiro SG, Porter J. Lung cancer Where are we today.'? Current advances in staging and nonsurgical treatment [ J ]. Am J Respir Crit Care Med, 2002, 166(9) : 1166 -1196.
  • 3Kruger AC, Raarup MK, Nielsen MM, et al. Interaction of hnRNP A1 with telomere DNA C - quadruplex structures studied at the sin- gle molecule level[ J]. Eur Biophys J, 2010, 39(9) : 1343 - 1345.
  • 4Visa N, Alzhanova-Ericsson AT, Sun X, et al. A pre -mRNA - binding protein accompanies the RNA from the gene through the nuclear pores and into polysomes [ J ]. Cell, 1996, 84 (2) : 253 - 264.
  • 5Chaudhury A, Chander P, Howe PH. Heterogeneous nuclear ribo- nucleoproteins (hnRNPs) in cellular processes: focus on hnRNP El's multifunctional regulatory roles [ J ]. RNA, 2010, 16 ( 8 ) : 1449 - 1462.
  • 6Mili S, Shu HJ, Zhao Y, et al. Distinct RNP complexes of shutt- ling hnRNP proteins with pre - mRNA and mRNA: candidate in- termediates in formation and export of mRNA [ J]. Mol Cell Biol, 2001, 21(21): 7307-7319.
  • 7Ushigome M, Ubagai T, Fukuda H, et al. Up- regulation of hnRNP A1 gene in sporadic human colorectal cancers [J]. Int J Oncol, 2005, 26(3): 635-640.
  • 8Gu W, Liu W, Shen X, et al. Emergence of heterogeneous nucle- ar ribonucleoprotein A2/B1 vs loss of E - cadherin: their recipro- cal immunoexpression profiles in human pancreatic cancer [ J ]. Ann Diagn Pathol, 2013, 17(1) : 14-17.
  • 9E1 - Mazny A, Sayed M, Sharaf S. Human telomerase reverse transcriptase messenger RNA (TERT mRNA) as a tumour marker for early detection of hepatocellular carcinoma[ J]. Arab J Gastro- enterol, 2014, 15(2) : 68 -71.
  • 10Yang M, Li L, Wang J, et al. Heterogeneous nuclear ribonucleo- proteins (hnRNPs) and human transformer - 2 - betal ( hTra2 - betal ) - regulated estrogen receptor - alpha improves prognosis of endometrial cancer [ J ]. Eur J Gynaecol Oncol, 2014, 35 (6) : 701 - 707.

二级参考文献24

  • 1曹箭,潘秦镜,李中林,刘树范.纤维支气管镜ThinPrep技术刷片细胞病理检查的诊断价值[J].中华肿瘤杂志,2006,28(7):536-538. 被引量:24
  • 2Zech VF,Dlaska M,Tzarkov A,et al.Prognostic and diagnostic relevance of hnRNP A2/B1,hnRNP B1 and S100 A2 in non-small cell lung cancer.Cancer Detect Prev,2006,30:395-402.
  • 3Zhou J,Mulshine JL,Unsworth EJ,et al.Purification and characterization of a protein that permits early detection of lung cancer.J Biol Chem,1996,271:10760-10766.
  • 4Walker RA.Quantification of immunohistochemistry-issues concerning methods,utility and semiquantitative assessment Ⅰ.Histopathology,2006,49:406-410.
  • 5Snead DR,Perunovic B,Cullen N,et al.hnRNP B1 expression in benign and malignant lung disease.J Pathol,2003,200:88-94.
  • 6Pino I,Pio R,Toledo G,et al.Altered patterns of expression of members of the heterogeneous nuclear ribonucleoprotein(hnRNP)family in lung cancer.Lung Cancer,2003,41:131-143.
  • 7Satoh H,Ishikawa H,Kamma H,et al.HnRNP A2/B1 proteins in nontumorous alveolar cells.Lung,2003,181:219-225.
  • 8Sueoka E,Goto Y,Sueoka N,et al.Heterogenous nuclear ribonucleoprotein B1 as a new marker of early detection for human lung cancers.Cancer Res,1999,59:1404-1407.
  • 9Auckley DH,Crowell RE,Heaphy ER,et al.Reduced DNA-dependent protein kinase activity is associated with lung cancer.Carcinogenesis,2001,22:723-727.
  • 10Park J,Chen L,Tockman MS,et al.The human 8-oxoguanine DNA N-glycosylase 1(hOGG1) DNA repair enzyme and its association with lung cancer risk.Pharmacogenetics,2004,14:103-109.

共引文献10

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部