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Increased levels of lipid metabolism and cystatin-C, but not glucose, affect virtual P vector

Increased levels of lipid metabolism and cystatin-C,but not glucose, affect virtual P vector
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摘要 Background In this study, we aimed to evaluate the impact of abnormal glucose, lipid and Cystatin-C on the virtual P vector characteristics, which haven' t been reported in previous studies. Methods 204 of non-diabetes mellitus (NDM), 130 of DM (type 2) and 39 of impaired glucose tolerance (IGT) patients were consecutively and retrospectively recruited. We selected a one-minute length of electrocardiogram at 4AM for analysis. After a series of calculating algorisms, we obtained the virtual planar P vector parameters. Results There were no significant differences in FPV, FPA, RSPV, RSPA, HPV and HPA groups. After adjusting confounding factors, the re- gression coefficients (RC) were estimated as follow: for FPV, female gender (RC -0.21, P = 0.02), triglyceride (RC -0.09, P 〈 0.01), RVOT (RC 0.03, P = 0.02); for RSPV, female gender (RC -0.21, P 〈 0.01), triglyceride (RC -0.10, P 〈 0.01), average heart rate (RC 0.01, P = 0.02); for HPV, triglyceride (RC -0.08, P 〈 0.001), LDL (RC -0.19, P 〈 0.01), Apo B (RC 0.67, P 〈 0.01); for RSPA, B type of blood (RC -22.06, P = 0.02), Cystatin-C (RC -72.79, P = 0.02), thickness of interventricular septum (RC 3.70, P = 0.01). Cystatin-C was suggested as a cure related to RSPA, and the cut-off point was 1.6 mg/L. There were no significant risk factors associated with FPA and HPA. There was no difference in virtual P vector among DM, IGT and NDM groups. Conclusion In- creased levels of lipid and Cystatin-C significantly impact the characteristics of virtual P vector, whereas glucose does not. These changes may come from a higher low voltage atrial area and abnormal orientation of atrial depolarization. Background In this study, we aimed to evaluate the impact of abnormal glucose, lipid and Cystatin-C on the virtual P vector characteristics, which haven' t been reported in previous studies. Methods 204 of non-diabetes mellitus (NDM), 130 of DM (type 2) and 39 of impaired glucose tolerance (IGT) patients were consecutively and retrospectively recruited. We selected a one-minute length of electrocardiogram at 4AM for analysis. After a series of calculating algorisms, we obtained the virtual planar P vector parameters. Results There were no significant differences in FPV, FPA, RSPV, RSPA, HPV and HPA groups. After adjusting confounding factors, the re- gression coefficients (RC) were estimated as follow: for FPV, female gender (RC -0.21, P = 0.02), triglyceride (RC -0.09, P 〈 0.01), RVOT (RC 0.03, P = 0.02); for RSPV, female gender (RC -0.21, P 〈 0.01), triglyceride (RC -0.10, P 〈 0.01), average heart rate (RC 0.01, P = 0.02); for HPV, triglyceride (RC -0.08, P 〈 0.001), LDL (RC -0.19, P 〈 0.01), Apo B (RC 0.67, P 〈 0.01); for RSPA, B type of blood (RC -22.06, P = 0.02), Cystatin-C (RC -72.79, P = 0.02), thickness of interventricular septum (RC 3.70, P = 0.01). Cystatin-C was suggested as a cure related to RSPA, and the cut-off point was 1.6 mg/L. There were no significant risk factors associated with FPA and HPA. There was no difference in virtual P vector among DM, IGT and NDM groups. Conclusion In- creased levels of lipid and Cystatin-C significantly impact the characteristics of virtual P vector, whereas glucose does not. These changes may come from a higher low voltage atrial area and abnormal orientation of atrial depolarization.
出处 《South China Journal of Cardiology》 CAS 2016年第1期36-44,共9页 岭南心血管病杂志(英文版)
关键词 abnormal glucose metabolism diabetes mellitus electrocardiography monitoring planar vector abnormal glucose metabolism diabetes mellitus electrocardiography monitoring planar vector
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参考文献24

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